Botulax 300UI
Clostridium botulinum toxin type A · 300 units · lyophilised powder, single-dose vial. Manufactured by Hugel, Inc, South Korea.
Original price was: $98.90.$95.90Current price is: $95.90.
You save
- Botulax 300UI is the largest unit-count vial in Hugel’s Botulax line, delivering triple the toxin content of the standard 100-unit option. It suits large muscle groups, chronic migraines, and stroke-related spasticity, alongside standard cosmetic applications.
Professional use only. This product is intended for administration by licensed healthcare practitioners trained in the relevant anatomy and injection technique. By ordering you confirm you are authorised to purchase and handle products of this class in your jurisdiction. Availability and permitted use vary by country — please verify local regulations before ordering.
In accordance with applicable U.S. FDA regulations, this product is not available for purchase or shipment to U.S. addresses through this website. Customers in the United States should obtain botulinum toxin products through appropriately licensed and authorized U.S. distribution channels. A valid medical license or registration certificate is required to process any product-related claim.
Did you like this product? Add to favorites now and follow the product.
(+82) 10 7364 7998 Send a message on WhatsApp.
The largest Botulax vial, for body work and high-volume clinics
Botulax 300UI is the largest presentation in Hugel’s botulinum toxin type A range. The formulation is identical to the 100 U and 200 U vials — what changes is the unit count, and therefore how far a single vial goes.
This size is aimed at practitioners doing substantial body work — masseter, platysma, trapezius, calf contouring — or running high-volume lists where smaller vials are exhausted quickly. A 300 U vial reduces both the number of reconstitutions per session and the per-unit handling cost.
It also demands more planning. Reconstituted product is single-patient use, so a 300 U vial only makes sense when a single patient’s treatment plan genuinely uses that many units. Opening one for a 40-unit glabellar treatment wastes most of it.
The same underlying formulation is marketed in the United States as Letybo (letibotulinumtoxinA-wlbg), approved by the FDA on 29 February 2024 for the temporary improvement in the appearance of moderate to severe glabellar lines following the BLESS I, II and III Phase III trials. That approval covers glabellar lines only, and a Korean-market Botulax carton is a separate registration from the US-labelled article.
Three times the units of the 100 U presentation, for body contouring and high-volume treatment lists.
The same formulation is approved in the US as Letybo for glabellar lines, supported by three Phase III trials.
Size exclusion chromatography separates the neurotoxin from residual process material, supporting batch consistency.
Reconstituted product is single-patient use, so this size suits a treatment plan that genuinely uses 300 units.
Why practitioners choose Botulax 300UI
Masseter, platysma, trapezius and calf work consume units quickly. One 300 U vial often replaces three 100 U vials in a single treatment plan.
One preparation rather than three removes handling steps and the chance of a dilution error mid-list.
Letybo, approved in the United States in February 2024 for glabellar lines, is the same underlying formulation.
100 U, 200 U and 300 U share one formulation, so vial size can change without changing product.
Aesthetic & therapeutic applications
The indication under which this formulation holds US approval, as Letybo, is set out first. The remaining areas are commonly treated in practice — and are where a 300-unit vial is typically used — but approval status differs between markets.
Masseter, platysma, trapezius and calf treatment for muscle contouring. This is the main reason practitioners choose the 300-unit vial. Approval status varies widely by country and this is frequently a practitioner-led application rather than a labelled indication.
Temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in adults. This is the sole indication covered by the February 2024 US approval of Letybo.
Lines at the outer eye produced by orbicularis oculi activity. Widely treated in aesthetic practice, though not covered by the US approval of the partner brand.
In some markets the manufacturer’s registration extends to conditions such as blepharospasm and post-stroke upper limb spasticity, where higher unit counts are often required. These vary considerably by country.
Botulinum toxin products are prescription-only medicines. Any use outside the indications approved in your jurisdiction is a clinical decision made by the treating practitioner under their own professional judgement and local regulatory framework. Korea Filler Experts supplies the product; nothing here should be read as a recommendation to treat any medical condition.
What is inside Botulax 300UI
| Active substance | Clostridium botulinum toxin type A |
| Strength | 300 Units per vial |
| Strain | Clostridium botulinum CBFC26 |
| Stabiliser | Human serum albumin, 1.0 mg |
| Tonicity agent | Sodium chloride |
| Pharmaceutical form | Lyophilised powder for solution for injection |
| Purification | Size Exclusion High Performance Liquid Chromatography (SE-HPLC) |
| Diluent | Preservative-free 0.9% sodium chloride injection (not supplied) |
| Container | Single-use glass vial with rubber stopper and flip-off cap |
| Route | Intramuscular injection |
| Manufacturer | Hugel, Inc, South Korea |
| Regulatory class | Prescription-only medicine (professional use) |
Reading the carton
Before you accept a delivery, check four things:
- The lot / batch number on the carton matches the number printed on the vial.
- The expiry date leaves you enough working life — we do not dispatch stock with under 6 months remaining unless agreed in advance.
- The flip-off cap is intact and the vial seal has not been disturbed.
- The carton arrived cold, with the coolant pack still chilled.
Vial looks empty? The contents are freeze-dried under vacuum, so even 300 units form a thin film that is hard to see against the glass. This is expected and is not a sign of a short fill.
What each component does
- Botulinum toxin type A — the active substance. It temporarily reduces the release of acetylcholine at the neuromuscular junction, lowering activity in the injected muscle.
- Human serum albumin — stabilises the toxin protein during freeze-drying, storage and reconstitution. The 300 U vial carries 1.0 mg, scaled to the larger fill.
- Sodium chloride — brings the reconstituted solution to a tonicity suitable for injection.
How to prepare and use Botulax 300UI
Reference information for licensed practitioners. Note that diluent volumes for a 300-unit vial are three times those of a 100-unit vial to reach the same concentration. Reconstitution and administration must follow the prescribing information approved in your market.
Step by step
-
Inspect the vial
It should be colourless and transparent, with white or pale yellow powder visible. Check the lot number and expiry date, and confirm the flip-off cap is intact.
-
Calculate the diluent volume
Work from the 300 U column, not from habit. A 300 U vial needs 7.5 mL to reach 4 units per 0.1 mL — three times what a 100 U vial would take.
-
Introduce the saline slowly
Insert the needle at an angle and let the vacuum draw the saline in. Direct the stream against the vial wall rather than onto the powder.
-
Mix gently
Rotate the vial slowly to dissolve the cake. Do not shake vigorously — agitation can denature the protein.
-
Confirm before drawing
The solution should be clear, colourless and free of particles. Discard the vial if it is cloudy, discoloured or contains visible matter.
-
Record and refrigerate
Note the reconstitution date and time on the vial, store at 2–8 °C, and use within the period stated in your approved prescribing information.
Dilution reference
| Diluent added | Units per 0.1 mL | Total volume |
|---|---|---|
| 3.0 mL | 10 U | 3.0 mL |
| 6.0 mL | 5 U | 6.0 mL |
| 7.5 mL | 4 U | 7.5 mL |
| 12.0 mL | 2.5 U | 12.0 mL |
| 15.0 mL | 2 U | 15.0 mL |
Administration notes
Check the vial size before you dilute. The volumes above are three times those for a 100 U vial. Adding 2.5 mL to a 300 U vial gives 12 units per 0.1 mL, not 4 — a serious overdose if the dose is calculated from habit. This is the single most important thing to get right when working with the larger presentations.
Materials needed: preservative-free 0.9% sterile saline, a sterile syringe (typically 30G), gloves and alcohol swabs. None of these are supplied with the vial.
- Units of botulinum toxin are product-specific. Do not convert or substitute units between brands.
- Dose per site, total dose and injection technique must follow the prescribing information approved in your market.
- Draw reconstituted product immediately before injection.
- Treatment intervals should not be shortened below the minimum stated in the prescribing information.
After treatment
- Avoid rubbing or massaging the treated area for at least 24 hours
- Stay upright and avoid lying down for 4 to 6 hours
- Avoid strenuous exercise for 24 to 48 hours
- Avoid saunas, hot tubs and excessive sun exposure for at least 24 hours
- Mild redness, swelling or bruising can occur and usually settles within a few days
Storing and handling Botulax 300UI
Store refrigerated at 2–8 °C in the original carton, protected from light. Do not freeze. Always work to the expiry date printed on the carton.
Keep at 2–8 °C and use within the period stated in your approved prescribing information. Single-patient use only — a reconstituted 300 U vial is not shared between patients, which is why session planning matters with this size.
Transfer stock into a monitored medical refrigerator on arrival and keep a temperature log. If a shipment arrives warm, photograph the packaging and contact us before putting it into clinical service.
Do not use the vial if the powder is discoloured, if the reconstituted solution is cloudy or contains particles, if the expiry date has passed, or if the cold chain is known to have been broken. Dispose of unused product and used vials as clinical waste in line with local requirements.
What's included with Botulax 300UI
Diluent (0.9% sodium chloride injection), syringes and needles are not supplied with this product and must be sourced separately. A 300 U vial needs considerably more diluent than smaller presentations — plan your saline stock accordingly.
Botulax 300UI — frequently asked questions
What is Botulax 300UI?
Botulax 300UI is the largest vial in Hugel’s botulinum toxin type A range, supplied as a sterile freeze-dried powder in a single 300-unit vial and reconstituted with preservative-free 0.9% sodium chloride before injection by a licensed practitioner.
How much saline does a 300 U vial need?
Three times what a 100 U vial takes. To reach 4 units per 0.1 mL you add 7.5 mL, where a 100 U vial would take 2.5 mL. Adding 2.5 mL to a 300 U vial would give 12 units per 0.1 mL — worth double-checking when switching vial size mid-list.
When is this size the right choice?
When a single patient’s treatment plan genuinely uses 300 units — substantial body work such as masseter, platysma, trapezius or calf contouring. Because reconstituted product is single-patient use, opening a 300 U vial for a 40-unit facial treatment wastes most of it.
Is Botulax the same as Letybo?
They share the same underlying formulation. Letybo (letibotulinumtoxinA-wlbg) is the brand Hugel markets in the United States, where it received FDA approval on 29 February 2024 for the temporary improvement in the appearance of moderate to severe glabellar lines.
They are separate registrations. A Korean-market Botulax carton is not the FDA-approved, US-labelled Letybo article, and the US approval covers glabellar lines only.
Is the formulation the same as the 100 U and 200 U vials?
Yes — same active substance, same strain, same excipients. Only the fill quantity differs, with albumin scaled to the larger fill.
Can I substitute Botulax units for another brand's units?
No. Units of botulinum toxin are specific to each product and are not interchangeable between brands. Dosing must be taken from the prescribing information for the product in your hand.
What shelf life will my stock have?
We do not dispatch stock with less than six months of remaining shelf life unless you have specifically agreed to it. If you need a particular expiry window, tell us before you order and we will allocate accordingly.
What happens if my shipment arrives warm?
Do not use it. Photograph the outer box, the insulated liner, the coolant packs and the vial carton, and contact us the same day with your order number. We will review the cold-chain evidence and arrange a replacement where the failure occurred in transit.
Who is allowed to buy this product?
Botulinum toxin is a prescription-only medicine. Purchase and use are restricted to licensed healthcare professionals qualified to prescribe or administer injectable prescription medicines in their jurisdiction, with appropriate training in the relevant anatomy and injection technique. We do not sell to consumers.
Customer Reviews
Share your experience with this product. Your honest review helps other customers make better choices.
- Sort By
- Newest
- Oldest
- Highest Rating
- Lowest Rating
Buying the larger size makes much more sense for our clinic. Good value overall.
We wanted the larger vial size for our clinic, and this was a practical choice.
The product was easy to arrange and the communication was good. I had a positive experience overall and would consider it again.
A very smooth purchase experience. Customer support was helpful, and the delivery process was faster than I thought.
Everything arrived exactly on schedule, which was important because my appointment had already been booked. The result looked fresh without making my face feel frozen.
The service team answered quickly and the package arrived without delay. The treatment worked, but the onset and duration were not as consistent for me as another toxin I have used previously.
Third time using this and it's been pretty consistent for me. Usually starts kicking in around day 4.
Easy treatment and an easy recovery.
No complaints. It delivered exactly what my injector explained.
Simple treatment, good outcome, nothing I'd change.
Copyright 2026 © Korea Filler Experts. All right reserved.
