Description

Botulax 300UI — High-Purity Botulinum Toxin Type A

Botulax 300UI is a botulinum toxin type A product from Hugel, Inc., one of South Korea’s largest and most established pharmaceutical manufacturers. This is the largest vial in the Botulax line, delivering three times the toxin content of the standard 100-unit option.

In the United States, Hugel markets this same underlying formulation under the brand name Letybo. Letybo received FDA approval in 2024, reflecting the depth of clinical study behind the Botulax formulation. Hugel purifies each batch to over 99% using Size Exclusion High Performance Liquid Chromatography (SE-HPLC).

At a Glance

Units per Vial	300 units
Onset	Visible within 4–6 weeks; early changes often sooner
Duration	3–4 months per session
Purity	>99% (SE-HPLC purification)
Manufacturer	Hugel, Inc., South Korea

Main Benefits

• Reduces visible wrinkles: relaxes facial muscles to smooth frown lines and crow’s feet
• Suits full-face or large-area treatment: 300 units per vial covers multiple areas or larger muscles in one session
• Consistent, long-lasting results: high purity supports reliable outcomes that last several months
• Approved for multiple uses: suits facial rejuvenation, blepharospasm, and muscle spasticity

What’s Inside

Active Ingredient	Clostridium botulinum toxin type A — 300 units
Stabilizer	Human serum albumin — 1.0mg
Additive	Sodium chloride
Strain	Clostridium Botulinum CBFC26
Format	Lyophilized powder, single-dose vial
Manufacturer	Hugel, Inc., South Korea

Packaging and included accessories (syringes, saline, gloves) vary by supplier — check your specific listing for exact kit contents.

How Botulax Is Made

Hugel purifies the active ingredient using Size Exclusion High Performance Liquid Chromatography, which removes impurities and supports consistent potency. The finished product arrives as a fine powder in a sterile vial, ready for reconstitution with 0.9% saline. Across multiple clinical trials, Botulax has shown stability, efficacy, and safety comparable to other established brands. It remains stable when stored at 2–8°C.

What Botulax Is Made Of

Clostridium Botulinum Toxin Type A	A purified neurotoxic protein that temporarily blocks nerve signals to targeted muscles, reducing dynamic facial wrinkles
Human Serum Albumin	A protein derived from human blood plasma, used to stabilize the toxin and maintain its effectiveness after reconstitution
Sodium Chloride	Helps balance the solution’s pH and tonicity for safe injection

Mechanism of Action

Once injected, botulinum toxin type A blocks the release of acetylcholine, the neurotransmitter responsible for triggering muscle contraction. Because the treated muscle can no longer contract as forcefully, the movement that causes wrinkles decreases. As a result, expression lines soften, creating a more refreshed appearance. When a trained professional administers it correctly, the effect stays localized to the injected muscle and does not spread through the body.

Preparation & Dilution

Botulax comes as a fine powder that must be reconstituted with saline before use. Because the powder is so fine, the vial can look nearly empty. This is normal, and the full dose remains present.

Materials needed: 0.9% sterile saline, a sterile syringe (typically 30G), latex gloves, and alcohol swabs.

Saline Added (300U vial)	Resulting Concentration
1.0mL	30 units per 0.1mL
2.0mL	15 units per 0.1mL
2.5mL	12 units per 0.1mL
4.0mL	7.5 units per 0.1mL
7.5mL	4 units per 0.1mL

1. Inspect the vial: it should be colorless and transparent with a small quantity of white or light yellow powder visible
2. Draw the saline into a syringe and slowly inject it into the vial
3. Gently swirl to mix — do not shake vigorously
4. Confirm the solution is clear and free of particles before drawing a dose
5. Store refrigerated at 2–8°C and use within 24 hours

Treatment Areas

Face:

• Glabellar lines (between the eyebrows)
• Forehead lines
• Crow’s feet
• Lower face and jawline (muscle contouring)
• Around the eyes (blepharospasm treatment)

Body:

• Areas affected by muscle spasticity
• Upper limbs (post-stroke spasticity)
• Lower limbs, including equinus foot deformity in children with cerebral palsy
• Neck and larger muscle groups requiring higher total unit counts

Dosage & Technique

Dosage and injection technique vary by treatment area and patient condition. A licensed professional trained in botulinum toxin injection should determine the exact plan. General reference guidelines include:

• Benign essential blepharospasm: injected into the muscles surrounding the eyes in adult patients
• Equinus foot deformity in cerebral palsy: administered to lower limb muscles in patients aged 2 and older
• Glabellar lines: used to treat moderate to severe frown lines from repeated facial expression
• Muscle spasticity: used for larger muscle groups where higher total unit counts are needed in one session

Post-Treatment Care

• Avoid rubbing or massaging the treated area for at least 24 hours
• Stay upright and avoid lying down for 4 to 6 hours after treatment
• Avoid strenuous exercise for 24 to 48 hours
• Skip saunas, hot tubs, and excessive sun exposure for at least 24 hours
• Delay facials, microdermabrasion, or chemical peels for at least 1 week
• Mild redness, swelling, or bruising can occur and usually resolves within a few days

Course of Treatment

1 session	Typically enough to achieve visible wrinkle reduction
3–4 months	How long results from a single session generally last
3–6 months	Recommended interval for repeat treatment to maintain results

Most patients notice initial changes within a few weeks. Clinical follow-ups often confirm visible improvement at the 4, 6, and 12-week marks.

Precautions

• For use by licensed medical professionals only
• Contraindicated in patients with neuromuscular junction disorders, such as myasthenia gravis
• Contraindicated during pregnancy or breastfeeding
• Avoid in patients with active infection at the injection site
• Proper training in injection technique and anatomy is essential, particularly for therapeutic applications

Storage & Handling

• Store unopened vials refrigerated at 2–8°C, away from light
• Do not freeze
• Use within 24 hours after reconstitution; some data suggests stability up to 5 weeks under refrigeration, though 24 hours remains the standard recommendation

Botulinum toxin type A is a prescription medical product for use by licensed healthcare professionals only. Botulax itself is distinct from the FDA-approved Letybo product marketed in the United States. Availability may be restricted for US customers, so check current regulations before ordering.

Frequently Asked Questions

What is Botulax 300UI?
Botulax 300UI is a high-purity botulinum toxin type A product from Hugel, offering the largest unit count in the Botulax line for treating large muscle groups and broader areas.

Are results immediate?
No. Most patients notice changes within a few weeks, with clinical studies showing improvement confirmed at 4, 6, and 12-week follow-ups.

Who is the 300UI vial best suited for?
Practitioners treating large muscle groups, chronic migraines, upper limb spasticity, or multiple facial areas in a single session often prefer it, since it reduces the need for several smaller vials.

How does 300UI differ from the 100UI and 200UI versions?
All three share the same formulation and manufacturer. The 300UI vial simply contains three times the toxin units of the 100UI vial, making it more practical for larger or combined treatment sessions.

Can Botulax 300UI treat conditions beyond wrinkles?
Yes. Beyond cosmetic use, it’s approved for benign essential blepharospasm and equinus foot deformity in patients over 2 years old, and it’s also used for muscle spasticity and hyperhidrosis.

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