Description

• Coretox 100 Units — Protein-Free Botulinum Toxin Type A

  Coretox 100 Units is a botulinum toxin type A product from Medytox Inc. in South Korea. Researchers recognize it as the world’s first 150kDa botulinum toxin free of any animal-derived components in both its toxin culture media and finished product. Rather than using human serum albumin (HSA) as a stabilizer, Coretox relies on polysorbate 20, sucrose, and L-methionine instead.

  Coretox removes the accessory complexing proteins found in many other botulinum toxin formulations. Because of this, it delivers only the pure neurotoxin itself. This lower total protein load is designed to reduce the risk of immune resistance developing over repeated treatments.

  At a Glance

  Units per Vial	100 units
  Onset	2–3 days
  Duration	Up to 12 months
  Regulatory Status	MFDS-approved (2016)
  Manufacturer	Medytox Inc., South Korea

  Main Benefits

  • Protein-free formulation: the world’s first 150kDa toxin free of animal-derived components and HSA
  • Reduced immunogenicity risk: lower total protein content supports long-term consistency without resistance buildup
  • Fast onset: visible results typically within 2 to 3 days
  • Long-lasting results: effects reported to last up to 12 months
  • Natural-looking outcomes: relaxes targeted muscles without an overly frozen appearance

  What’s Inside

  Active Ingredient	Clostridium botulinum toxin type A (Hall strain) — 100 units
  Stabilizers	Polysorbate 20, sucrose, L-methionine
  Human Serum Albumin	None
  Format	Lyophilized white powder, single-dose vial
  Manufacturer	Medytox Inc., South Korea

  Coretox carries MFDS approval in South Korea. It is not FDA-approved in the United States.

  Mechanism of Action

  Coretox blocks the release of acetylcholine at the neuromuscular junction, temporarily reducing activity in the targeted muscle. Because the formula contains no complexing proteins, only the active neurotoxin itself reaches the injection site, which is part of why practitioners associate it with a cleaner, more predictable response over repeated treatments.

  Preparation & Dilution

  Reconstitute the 100-unit vial with 2.5mL of sterile saline, producing a standard concentration of 4 units per 0.1mL. Because the powder is freeze-dried, the vial can look nearly empty before reconstitution — a small amount of white powder should still be visible at the bottom.

  1. Inspect the vial for an intact seal and colorless, transparent powder
  2. Draw 2.5mL of sterile saline and inject it gently into the vial
  3. Swirl gently to dissolve — avoid shaking
  4. Use within 24 hours of reconstitution, storing refrigerated at 2–8°C in the meantime

  Indications

  • Moderate to severe glabellar lines (frown lines)
  • Forehead lines
  • Crow’s feet
  • Jawline contouring

  Dosage & Technique

  For glabellar lines, a standard protocol uses 20 units, producing a visible reduction in frown line severity. Exact dosing and injection sites for other areas should follow labeled recommendations and be tailored to each patient’s anatomy and treatment history.

  Precautions

  • For use by licensed medical professionals only
  • Contraindicated in patients with known hypersensitivity to any botulinum toxin preparation or formulation component
  • Contraindicated in the presence of infection at the proposed injection site
  • Not interchangeable on a unit-for-unit basis with other botulinum toxin products
  • Rare cases of distant toxin spread have been reported, sometimes appearing hours to weeks after injection

  Storage & Handling

  • Store unopened vials refrigerated at 2–8°C, protected from light
  • Do not freeze
  • Shelf life is 36 months from the manufacturing date
  • Use within 24 hours after reconstitution

  Botulinum toxin type A is a prescription medical product for use by licensed healthcare professionals only.

  Frequently Asked Questions

  What is Coretox 100 Units?
  Coretox 100 Units is a protein-free botulinum toxin type A from Medytox, free of human serum albumin and other animal-derived components, used to reduce dynamic facial wrinkles.

  Why doesn’t Coretox contain human serum albumin?
  Medytox developed Coretox specifically to remove HSA and complexing proteins from the formula, aiming to lower total protein content and reduce the risk of immune resistance over repeated treatments.

  How long do results last?
  Results are reported to last up to 12 months, though this varies by treatment area and individual patient factors.

  Why does the vial look nearly empty?
  Coretox’s freeze-dried powder is very fine, so little is visible at the bottom of the vial. The full 100-unit dose is present and dissolves completely once reconstituted.

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