Description

Olidia 365mg — PLLA Collagen Biostimulator

Olidia 365mg is a poly-L-lactic acid (PLLA) collagen biostimulator from PRP Life Science in South Korea, carrying both KFDA approval and CE certification. Rather than adding immediate physical volume like an HA filler, it works beneath the skin. There, it stimulates the body’s own collagen production.

PLLA is a synthetic, biocompatible material with more than 20 years of use in medical devices. Because of this, Olidia doesn’t require allergy testing before treatment. Practitioners use it to correct nasolabial folds, contour deficiencies, and facial wrinkles as results build gradually over several weeks.

At a Glance

Total Composition	365mg per vial
Onset	Collagen deposition peaks around 6–8 weeks
Duration	Up to 24 months; ~80% benefit retained at 25 months
Regulatory Status	KFDA approved, CE certified
Manufacturer	PRP Life Science Co., Ltd., South Korea

Main Benefits

• Stimulates natural collagen production: works with the body’s own fibroblasts rather than just adding volume
• Long-lasting results: up to 24 months, among the longer durations for biodegradable facial fillers
• No allergy testing required: fully synthetic, biocompatible formulation
• Clinically studied: supported by registered trial data (NCT04568902) showing volume retention and collagen increase
• Natural-looking, gradual results: improvement builds over weeks rather than appearing all at once

What’s Inside

Poly-L-Lactic Acid (PLLA)	150mg
Carboxymethylcellulose (CMC)	90mg
Mannitol	125mg
Format	Sterile, lyophilized powder for reconstitution
Packing	1 × 5mL vial (365mg total)
Manufacturer	PRP Life Science Co., Ltd., South Korea

Olidia carries KFDA and CE certification. It is not FDA-approved as a finished product, though PLLA as a raw material has a long history of use in other FDA-recognized medical devices.

How Olidia Works

Once injected, PLLA microparticles trigger a controlled inflammatory response that prompts fibroblasts to produce new collagen. This process, known as neocollagenesis, builds volume gradually from within. It works differently from a filler material simply sitting under the skin.

Collagen deposition typically peaks around 6 to 8 weeks after treatment. Because of this, results continue to develop well after the injection itself. Meanwhile, the PLLA scaffold gradually hydrolyzes into carbon dioxide and water, which the body clears naturally as newly formed collagen takes its place. This process unfolds over time. As a result, published data suggests roughly 80% of the volumizing benefit remains at 25 months post-treatment.

Who Olidia Suits

Practitioners recommend Olidia for adult patients with:

• Shallow to deep nasolabial folds
• Facial contour deficiencies and lipoatrophy
• General facial wrinkles associated with volume loss
• Patients seeking longer-lasting results than typical HA fillers provide

Preparation & Dilution

Practitioners dilute one vial with 7mL of saline and 2mL of lidocaine to create a 9mL suspension, yielding three 3mL syringes per vial. The powder needs time to fully hydrate. Because of this, many practitioners prepare the suspension several hours before injection, or the night before, to support smoother administration.

Treatment Areas

Nasolabial folds · Cheeks and mid-face contour · Temples · Areas affected by facial lipoatrophy

Recommended Treatment Course

Most patients complete an initial series of 3 to 4 sessions, spaced several weeks apart, to build up collagen gradually. The resulting collagen remains in place for an extended period. Because of this, most patients don’t need further treatment for another 2 to 3 years after completing the initial series.

Precautions

• For use by a licensed medical professional or dermatologist only
• Not recommended during pregnancy or breastfeeding
• Avoid in patients with a history of keloid scarring or active skin infection at the injection site
• Discuss any autoimmune conditions with the patient before treatment

Storage & Handling

• Store at room temperature, away from direct light
• Reconstitute in advance to allow the powder to fully hydrate
• Single-use only — do not reuse or resterilize

Frequently Asked Questions

What is Olidia 365mg?
Olidia is a PLLA-based collagen biostimulator from PRP Life Science, designed to correct nasolabial folds, contour deficiencies, and facial wrinkles by stimulating the body’s own collagen production.

How is Olidia different from HA fillers?
Rather than adding immediate physical volume, Olidia works beneath the surface to stimulate new collagen. Results build gradually over weeks. Even so, they also tend to last considerably longer.

How long do results last?
Results typically last up to 24 months, with roughly 80% of the benefit still present at 25 months according to published data.

Does Olidia require allergy testing?
No. Because Olidia is made from synthetic, biocompatible PLLA, it doesn’t require allergy testing before treatment.

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