Nabota 100UI – Copy
Purified botulinum toxin type A, supplied as a sterile lyophilised powder for reconstitution. Single 100-unit vial.
$68.90
| Quantity | Discount | Price / unit |
|---|---|---|
| 1 – 4 vials | — | $68.90 |
| 5 – 9 vials | 4.8 % off | $65.60 |
| 10 – 19 vials | 9.5 % off | $62.35 |
| 20 + vials | 14.3 % off | $59.00 |
Volume pricing is applied automatically at checkout.
Botulinum toxin type A manufactured by Daewoong Pharmaceutical in South Korea. Supplied as a sterile lyophilised powder in a single 100-unit vial for reconstitution before use. For administration by licensed healthcare professionals.
- Sourced through licensed Korean distribution channels
- Validated cold chain, 2–8 °C end to end
- Batch number and expiry visible before dispatch
- Practitioner support from our clinical team
Professional use only. This product is intended for administration by licensed healthcare practitioners who are trained in facial anatomy and injection technique. By ordering you confirm you are authorised to purchase and handle prescription-only medicines in your jurisdiction. Availability and permitted use vary by country — please verify local regulations before ordering.
A valid medical license or registration certificate is required to process any claim.
Important Information for Customers in the United States:
To support regulatory compliance and promote patient safety, we would like to notify our U.S. customers about current guidance issued by the U.S. Food and Drug Administration (FDA) concerning the online purchase of injectable botulinum toxin products.
Under FDA regulations, certain prescription injectable products, including botulinum toxin, may only be supplied through authorized distribution channels. For this reason, we recommend that customers in the United States obtain these products only from licensed healthcare providers or authorized U.S. distributors who are permitted to distribute prescription medical products.
As part of our ongoing compliance efforts, we are reviewing our website, including product listings, category organization, and U.S. purchasing policies, to ensure all content and product availability remain consistent with applicable regulatory requirements. During this review, some products may be temporarily unavailable or have restricted access for customers located in the United States.
We appreciate your patience and understanding while these updates are being implemented. These measures are intended to strengthen compliance, improve transparency, and maintain the highest standards of customer safety and regulatory responsibility.
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A Korean-manufactured botulinum toxin type A, built for consistent day-to-day clinic use
Nabota is the botulinum toxin type A product developed and manufactured by Daewoong Pharmaceutical, one of South Korea’s largest pharmaceutical companies. It launched in the Korean market in 2014 and the same active substance — prabotulinumtoxinA — later became the first Asian-manufactured botulinum toxin to gain United States FDA approval, where it is marketed by a licensed partner under a different brand name.
Produced under pharmaceutical GMP conditions
Nabota is manufactured at Daewoong’s dedicated biologics facility in South Korea under Good Manufacturing Practice requirements enforced by Korea’s Ministry of Food and Drug Safety. Production covers strain culture, purification of the toxin complex, formulation with stabilising excipients, and freeze-drying into single-use vials.
Each finished batch is released against defined specifications for potency, sterility, endotoxin and appearance. The vial you receive carries a printed lot number and expiry date that can be matched to the manufacturer’s release documentation.
One vial, 100 units, no partial-fill guesswork
Nabota 100U is supplied as a white to off-white lyophilised (freeze-dried) powder in a clear glass vial sealed with a rubber stopper and aluminium flip-off cap. Because the powder is vacuum-dried, the vial can look almost empty — this is normal and does not indicate a missing or defective product.
The vial is reconstituted with preservative-free 0.9 % sodium chloride injection immediately before use. Dilution volume determines the final concentration, which lets you match unit delivery to your preferred injection volume.
Traceable from the manufacturer to your clinic
Every carton we dispatch carries the manufacturer’s printed lot number and expiry date. We can confirm both before your order leaves us, so the stock arriving at your clinic is the stock you agreed to buy.
We do not ship product with less than six months of remaining shelf life unless you have specifically agreed to it in advance. If you need a particular expiry window for a scheduled treatment programme, tell us before you order and we will allocate accordingly.
Kept at 2–8 °C from our facility to your door
Botulinum toxin is temperature-sensitive, and a broken cold chain is the most common reason a shipment has to be written off. Orders leave us in an insulated liner with conditioned coolant packs sized to the transit time and destination climate.
On arrival, transfer the carton straight into a monitored medical refrigerator and log the temperature. If a shipment reaches you warm, photograph the outer box, the liner and the coolant packs before opening anything further, and contact us the same day.
Why practitioners stock Nabota
Feature descriptions below reflect the product’s presentation and published clinical study findings. Individual patient outcomes vary with dose, technique, anatomy and treatment history.
Two identical randomised, double-blind, placebo-controlled Phase III studies in adults with moderate to severe glabellar lines reported responder rates of 67.5 % and 70.4 % versus 1.2 % and 1.3 % for placebo.
In published trials the effect on glabellar lines developed over the first days after injection and was sustained over a treatment cycle typically measured in months, supporting straightforward scheduling of review appointments.
Each vial contains botulinum toxin type A with human serum albumin as a stabiliser and sodium chloride for tonicity — a conventional, well-characterised excipient profile.
Reconstitution volume is chosen by the practitioner, allowing the same 100 U vial to be prepared at different concentrations to suit the treatment area and preferred injection volume.
Approved use
The approved indication for the active substance in this product, as reflected in the regulatory labelling of prabotulinumtoxinA, is set out below. Approved wording differs between markets — always work from the prescribing information registered in the country where you practise.
For the temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in adult patients.
In some markets the manufacturer’s registration covers further indications. Because these vary by country, we do not list them here. Consult the prescribing information approved for your market.
Botulinum toxin products are prescription-only medicines. Any use outside the indications approved in your jurisdiction is a clinical decision made by the treating practitioner, under their own professional judgement and local regulatory framework. Korea Filler Experts supplies the product; we do not provide treatment protocols for unapproved uses and nothing on this page should be read as a recommendation to treat any medical condition.
What is in each vial
| Active substance | Clostridium botulinum toxin type A (haemagglutinin complex) |
| Strength | 100 Units per vial |
| Stabiliser | Human serum albumin |
| Tonicity agent | Sodium chloride |
| Pharmaceutical form | Lyophilised powder for solution for injection |
| Appearance | White to off-white cake or powder |
| Diluent | Preservative-free 0.9 % sodium chloride injection (not supplied) |
| Container | Type I glass vial, rubber stopper, aluminium flip-off cap |
| Route | Intramuscular injection |
| Manufacturer | Daewoong Pharmaceutical Co., Ltd., Republic of Korea |
| Regulatory class | Prescription-only medicine (professional use) |
Reading the carton
Genuine Korean-market cartons are printed primarily in Korean with the product name in Latin script. Before you accept a delivery, check four things:
- The lot / batch number on the carton matches the number printed on the vial label.
- The expiry date leaves you enough working life — we do not dispatch stock with under 6 months remaining unless agreed in advance.
- The flip-off cap is intact and the vial seal has not been disturbed.
- The carton arrived cold, with the coolant pack still chilled.
Vial looks empty? Because the contents are freeze-dried under vacuum, the powder often forms a thin film that is hard to see against the glass. An apparently empty vial is expected and is not a sign of a short-filled or counterfeit product.
How botulinum toxin type A works
This is a general pharmacological description of the class, provided for professional reference.
After intramuscular injection the toxin binds with high affinity to receptors on presynaptic cholinergic nerve terminals at the neuromuscular junction.
The light chain is internalised and cleaves SNAP-25, a protein required for the vesicle fusion that releases acetylcholine into the synaptic cleft.
Neurotransmitter release is reduced, temporarily lowering activity in the injected muscle. The effect is not permanent: nerve terminal function recovers over time, which is why treatment is repeated.
Reconstitution and dilution
Reference information for licensed practitioners. Reconstitution and administration must follow the prescribing information approved in your market and your own clinical governance procedures.
Step by step
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Bring the vial to working condition
Take the vial from refrigerated storage and inspect the label, lot number and expiry. Confirm the flip-off cap is intact.
-
Prepare the diluent
Draw the required volume of preservative-free 0.9 % sodium chloride injection into a sterile syringe.
-
Disinfect the stopper
Remove the flip-off cap and wipe the exposed rubber stopper with an alcohol swab. Allow it to dry.
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Introduce the diluent slowly
Insert the needle at an angle and let the vacuum draw the saline in. Direct the stream against the vial wall rather than onto the powder.
-
Mix gently
Rotate the vial slowly to dissolve the cake. Do not shake vigorously — agitation can denature the protein. The solution should be clear, colourless and free of particulates.
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Record and use promptly
Note the reconstitution date and time on the vial. Keep the reconstituted vial refrigerated at 2–8 °C and use within the period stated in your approved prescribing information.
Do not use the vial if the powder is discoloured, if the reconstituted solution is cloudy or contains particles, if the expiry date has passed, or if the cold chain is known to have been broken. Unused product and used vials must be inactivated and disposed of as clinical waste in line with local requirements.
Dilution reference
| Diluent added | Units per 0.1 mL | Total volume |
|---|---|---|
| 1.0 mL | 10.0 U | 1.0 mL |
| 1.25 mL | 8.0 U | 1.25 mL |
| 2.0 mL | 5.0 U | 2.0 mL |
| 2.5 mL | 4.0 U | 2.5 mL |
| 4.0 mL | 2.5 U | 4.0 mL |
| 5.0 mL | 2.0 U | 5.0 mL |
Administration notes
- Units of botulinum toxin are product-specific. Do not convert or substitute units between different botulinum toxin brands.
- Injection technique, dose per site and total dose must follow the approved prescribing information for your market.
- A fine-gauge needle appropriate to the treatment area is normally used; reconstituted product is drawn immediately before injection.
- Treatment intervals should not be shortened below the minimum stated in the prescribing information.
What the clinical studies observed
The timeline below summarises findings from published randomised trials of prabotulinumtoxinA in glabellar lines. It describes study populations, not a guarantee of individual results. Response varies between patients.
Onset of visible effect is typically reported within the first few days after injection.
Primary efficacy endpoint in the Phase III programme; responder rates of 67.5 % and 70.4 % versus placebo.
Typical interval at which many patients in aesthetic practice are reviewed for retreatment.
A separate Phase II study of a 40 U dose reported a duration of effect of approximately six months.
Muscle mass, baseline line severity, dose delivered, injection placement, metabolism and treatment history all influence both how quickly an effect appears and how long it lasts. A patient’s first cycle may behave differently from later ones.
Keeping the product within specification
Store refrigerated at 2–8 °C in the original carton, protected from light. Do not freeze. Shelf life is up to 36 months from manufacture — always work to the printed expiry date.
Keep at 2–8 °C and use within the period specified in the approved prescribing information for your market. Do not freeze reconstituted solution. Single-patient use only.
Inactivate residual product and dispose of vials, needles and syringes as clinical/biohazardous waste in accordance with local regulations. Do not return unused product to general waste.
Refrigerated stock should be transferred to a monitored medical refrigerator on arrival. Keep a temperature log. If a shipment arrives warm, photograph the packaging and contact us before use — do not put questionable stock into clinical service.
What you receive
Diluent (0.9 % sodium chloride injection), syringes and needles are not supplied with this product and must be sourced separately.
Important safety information
Summarised for professional reference. It is not a substitute for the full approved prescribing information, which must be read before use.
Effects of botulinum toxin products may, in rare cases, extend beyond the injection site. Symptoms consistent with distant spread — including generalised muscle weakness, vision changes, difficulty swallowing, speaking or breathing — have been reported hours to weeks after injection and require immediate medical attention. Patients and carers should be counselled to seek urgent care if these occur.
Do not use where there is
- Known hypersensitivity to any botulinum toxin preparation or to any excipient, including human serum albumin
- Infection or inflammation at the proposed injection site
- Any contraindication listed in the prescribing information approved in your market
Use with particular caution in
- Patients with neuromuscular disorders such as myasthenia gravis, Lambert-Eaton syndrome or motor neurone disease, who may be at greater risk of clinically significant systemic effects
- Patients taking aminoglycoside antibiotics, muscle relaxants or other agents that interfere with neuromuscular transmission
- Patients with swallowing or breathing difficulties, or a history of aspiration
- Pregnancy and breastfeeding — safety has not been established
Commonly reported adverse reactions
Reactions reported with botulinum toxin type A injection for glabellar lines include injection-site pain, bruising, swelling or erythema, headache, eyelid ptosis, and brow asymmetry. Most are localised and transient.
Suspected adverse reactions should be reported through the pharmacovigilance system operating in your country. Reporting helps maintain safety monitoring for these products.
Published data on prabotulinumtoxinA
We cite peer-reviewed sources rather than internal marketing figures. Where a claim is not supported by a published study, we do not make it.
Two identical 150-day, randomised, double-blind, placebo-controlled single-dose studies enrolled adults with moderate to severe glabellar lines (n = 330 and n = 324), randomised 3:1 to 20 U prabotulinumtoxinA or placebo.
Day-30 responder rates were 67.5 % and 70.4 % in the active groups versus 1.2 % and 1.3 % for placebo (both p < .001). No serious adverse event in either study was assessed as related to the study drug.
A multicentre, randomised, double-blind, active-controlled Phase II trial evaluated a 40 U dose of prabotulinumtoxinA-xvfs for moderate to severe glabellar lines.
The 40 U dose was observed to be safe in the study population, with a duration of effect of approximately six months.
- Daewoong Pharmaceutical — biologics product information. View source
- Clinical applications and historical perspectives of prabotulinumtoxinA-xvfs. Dermatological Reviews. View source
- Efficacy and Safety of PrabotulinumtoxinA for the Treatment of Glabellar Lines in Adult Subjects: Results From 2 Identical Phase III Studies. Dermatologic Surgery 2019;45(11). View source
- Safety and Duration of Effect of 40-Unit PrabotulinumtoxinA-xvfs for Moderate to Severe Glabellar Lines: A Phase II, Multicenter, Randomized, Double-Blind, Active-Controlled Trial. View source
How your order travels
Vials are packed in an insulated liner with conditioned coolant packs sized to the transit time and destination climate.
Orders confirmed before the daily cut-off are dispatched the same working day. A tracking number is issued on dispatch.
Typical transit is 2–7 working days depending on destination. Standard shipping is $30; free on orders over $300.
Import rules for prescription medicines differ from country to country. It is the buyer’s responsibility to confirm that they are permitted to import and use this product in their jurisdiction, and to meet any licensing, registration or customs requirements that apply. Duties and import taxes, where charged, are payable by the recipient.
Frequently asked questions
What exactly is Nabota 100U?
Nabota 100U is a botulinum toxin type A product manufactured by Daewoong Pharmaceutical in South Korea. It is supplied as a sterile, freeze-dried powder in a single 100-unit vial and is reconstituted with preservative-free 0.9 % sodium chloride before injection by a licensed practitioner.
Is Nabota the same thing as the FDA-approved product?
The active substance in Nabota — prabotulinumtoxinA — is the same active substance that received United States FDA approval in February 2019, where it is marketed under a different brand name by a licensed commercial partner. Nabota is the brand under which Daewoong markets the product in Korea and various other markets.
Those are separate registrations. A Korean-market Nabota carton is not the FDA-approved, US-labelled article, and we do not represent it as such. Practitioners should confirm what is approved and lawfully supplied in their own country before ordering.
Why does the vial look empty?
The contents are freeze-dried under vacuum, so 100 units of active substance form only a very thin, almost transparent film on the base or wall of the vial. This is completely normal for lyophilised botulinum toxin products and is not an indication of a short fill or a counterfeit product. The powder becomes obvious once saline is introduced.
How should I dilute a 100U vial?
Dilution volume is chosen by the practitioner to achieve the concentration they prefer. Adding 2.5 mL of preservative-free 0.9 % sodium chloride gives 4 units per 0.1 mL, which is a commonly used concentration; the reference table in the Preparation section above lists other volumes. Always follow the reconstitution instructions in the prescribing information approved for your market.
How long does an effect last?
Published trials of prabotulinumtoxinA in glabellar lines measured the primary endpoint at day 30, and a Phase II study of a 40 U dose reported a duration of effect of around six months. In routine aesthetic practice, patients are commonly reviewed at three to four months. Individual duration varies with dose, muscle mass, technique and patient factors, so no specific duration can be promised.
Can I store the vial at room temperature?
No. Store unopened vials refrigerated at 2–8 °C in the original carton, protected from light, and do not freeze. Reconstituted solution should also be kept at 2–8 °C and used within the period stated in your approved prescribing information.
Do you ship to my country?
We ship to most destinations worldwide using temperature-controlled packaging, but import rules for prescription medicines vary considerably. Before placing a large order, contact our team with your destination country and we will tell you what we can and cannot ship there. Ultimately, confirming that you are permitted to import and use the product is the buyer’s responsibility.
Who is allowed to buy this product?
Botulinum toxin is a prescription-only medicine. Purchase and use are restricted to licensed healthcare professionals who are qualified to prescribe or administer injectable prescription medicines in their jurisdiction, and who have appropriate training in facial anatomy and injection technique. We do not sell to consumers.
What happens if my shipment arrives warm?
Do not use it. Photograph the outer box, the insulated liner, the coolant packs and the vial carton, and contact us the same day with your order number. We will review the cold-chain evidence and arrange a replacement where the failure occurred in transit.
Can I get a batch number and expiry date before I order?
Yes. Ask our team and we will confirm the lot number and expiry date of the stock allocated to your order before it is dispatched. We do not ship product with less than six months of remaining shelf life unless you have specifically agreed to it.
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We received our shipment in middle east within 5 days. very fast service. Product looks perfect condition.
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