Description

• Monalisa — Hy-BRID Hyaluronic Acid Filler Series

  Monalisa is a hyaluronic acid (HA) dermal filler series from GENOSS Co., Ltd., a South Korean medical device company established in 2007. The series uses GENOSS’s proprietary Hy-BRID technology. This stands for Hyper cross-linked, Based on non-animal HA, Residue-free, and Improved Density and elasticity.

  Hy-BRID technology produces uniformly dense HA particles. Because of this, Monalisa achieves a balance of viscoelasticity and long-lasting volume across its four variants. The line is distributed in 24 countries worldwide.

  At a Glance

  HA Concentration	24mg/mL across the series
  Technology	Hy-BRID cross-linking
  BDDE Residue	Less than 2ppm
  Duration	Up to 6–12 months, depending on variant
  Manufacturer	GENOSS Co., Ltd., South Korea

  Main Benefits

  • Uniform, dense HA particles: Hy-BRID technology supports consistent viscoelasticity and durability
  • Low BDDE residue: under 2ppm, helping minimize the risk of allergic reactions and edema
  • Non-animal HA: produced through bacterial fermentation, with no animal proteins or by-products
  • Ergonomic syringe design: consistent injection force supports precise, controlled treatment

  Choosing the Right Variant

  Variant	Particle Size	Best For	Injection Depth
  Monalisa Soft	200 μm	Tear troughs, superficial imperfections	Superficial dermis
  Monalisa Mild	400 μm	Cheek volume, perioral lines, glabella, nasolabial folds	Mid dermis
  Monalisa Hard	600 μm	Medium-to-deep wrinkles, lip augmentation, chin and jawline	Deep dermis
  Monalisa Ultra	900 μm	Nose, chin, and jawline contouring; non-surgical rhinoplasty	Deep subcutaneous

  What’s Inside

  Active Ingredient	Cross-linked Hyaluronic Acid — 24mg/mL
  Anesthetic	Lidocaine — 0.3% (available with or without, depending on variant)
  pH	7.0–7.10
  Packing	1 × 1mL prefilled syringe, plus 2 needles
  Manufacturer	GENOSS Co., Ltd., South Korea

  How Monalisa Works

  Hy-BRID technology cross-links HA into uniform, high-density particles. Because particle size varies by variant, each formulation behaves differently once injected. Smaller particles like those in Monalisa Soft flow smoothly into superficial tissue. Larger particles like those in Monalisa Ultra, on the other hand, hold their shape for structural support in deeper layers.

  This same manufacturing process also limits residual BDDE, the cross-linking agent used during production, to under 2ppm. Because leftover BDDE can affect the body if absorbed, keeping residue low supports a safer overall profile. The HA itself comes from bacterial fermentation rather than animal sources, which also reduces the risk of certain allergic reactions.

  Who Monalisa Suits

  Practitioners recommend Monalisa for patients interested in:

  • Correcting fine lines and superficial skin imperfections
  • Restoring cheek and facial volume
  • Lip augmentation and perioral contour
  • Correcting medium-to-deep wrinkles and nasolabial folds
  • Non-surgical nose, chin, and jawline contouring

  Treatment Areas

  Tear troughs · Glabellar lines · Nasolabial folds · Marionette lines · Perioral area and lips · Cheeks · Chin · Nose · Jawline · Forehead contour

  Injection Technique

  Monalisa’s syringes use ergonomic grips and push rods designed to maintain consistent injection force throughout the procedure. This supports precise, controlled placement. It also allows practitioners to adapt their technique to the specific treatment area, whether working superficially with Monalisa Soft or in deeper planes with Monalisa Ultra.

  Storage & Handling

  • Store at room temperature
  • Use immediately upon opening
  • Single-use only — do not reuse or resterilize
  • For professional use only, by qualified and trained practitioners

  Not recommended during pregnancy or breastfeeding, in patients with known hypersensitivity to HA, or in areas with active skin infection or inflammation. Patients with severe allergies to gram-positive bacterial proteins should avoid HA fillers produced through bacterial fermentation.

  Frequently Asked Questions

  What is Monalisa?
  Monalisa is a hyaluronic acid dermal filler series from GENOSS, built on Hy-BRID cross-linking technology and available in four variants for different correction depths.

  How do I choose between Soft, Mild, Hard, and Ultra?
  Monalisa Soft suits superficial areas like tear troughs, Mild suits cheek volume and perioral lines, Hard suits medium-to-deep wrinkles and lip augmentation, and Ultra suits deep structural contouring like the jawline and nose.

  Does Monalisa contain lidocaine?
  Most variants are available both with and without 0.3% lidocaine, so practitioners can choose based on patient preference.

  How long do results last?
  Results generally last 6 to 12 months, depending on the variant and treatment area.

  Can Monalisa be combined with other injectables?
  Yes. Practitioners commonly combine it with other HA fillers, botulinum toxin, or biostimulators within the same session. As always, they should follow appropriate intervals and manufacturer guidance.

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