Description

Proluma PLLA 365mg (CE) — Deep Volumizing Collagen Biostimulator by Genèse Labs

Proluma PLLA is a next-generation injectable collagen stimulator from Genèse Labs in Paris, France. It holds CE certification as a Class III medical device and won the Best Winner Award at Cosmoprof Asia Hong Kong.

Unlike HA fillers, which add volume immediately but fade within months, Proluma PLLA works beneath the surface to trigger deep, long-term collagen regeneration. Consequently, results build gradually and evolve naturally over time, rather than appearing all at once.

Formulated with high-purity poly-L-lactic acid, Proluma PLLA suits deep volume loss and structural facial support. Each box contains 365mg × 15 vials.

Korea Filler Experts offers Proluma PLLA and ships it worldwide.

Key Benefits

• Triggers deep, prolonged collagen stimulation rather than simply filling space
• Does not migrate and does not attract water, unlike many traditional fillers
• Delivers powerful, long-lasting lifting effects for deep wrinkles and volume loss
• Carries a lower risk of intravascular occlusion than traditional fillers
• Lasts up to 24+ months, outlasting HA fillers and many biostimulators
• Breaks down safely — PLLA is biodegradable, non-toxic, and GRAS-approved by the US FDA

What’s Inside

Ingredients	PLLA (Poly-L-lactic acid)
Composition	PLLA 41%, CMC 25%, Mannitol 34%
Molecular Weight	Approx. 100,000–300,000 Da
Microspheres	40–60 µm (crystalline, high crystallinity)
Cannula	26G or 25G, depending on practitioner preference
Injection Force	Approx. 3.5–4.0 N, depending on dilution
Harmful Residue	≤ 0.01 EU/mg (per CE and KFDA guidelines)
Dissolution Time	3 hours
Packing	365mg × 15 vials
Manufacturer	Genèse Labs, Paris, France

Why PLLA Contains Mannitol

Because PLLA’s crystalline structure is more rigid than PDLLA’s, it needs mannitol to stabilize the microspheres during freeze-drying and to aid reconstitution. Mannitol also improves suspension fluidity, which can ease injection comfort. This formulation approach follows a well-established precedent set by earlier PLLA-based biostimulators.

How Proluma PLLA Works

Proluma PLLA targets structural restoration through deep collagen biostimulation. Its highly crystalline particles stimulate fibroblasts to produce new collagen over an extended period, so facial contours and firmness improve progressively rather than all at once.

By weeks 4–6, initial fibroblast activation and matrix remodeling begin, bringing gradual improvement in skin density. By week 12, collagen fibers form a stable matrix around the PLLA microspheres, restoring facial volume naturally. Then, by weeks 16–24, advanced tissue remodeling delivers visible lifting, enhanced elasticity, and refined facial contours.

Eventually, the PLLA scaffold hydrolyzes into lactic acid, which the body metabolizes into carbon dioxide and water. Meanwhile, the newly formed collagen matrix remains, so results continue to evolve naturally for months after treatment.

Who Is Proluma PLLA Suited For?

Proluma PLLA suits patients in their 40s to 60s who present with advanced volume loss and facial sagging. Because its crystalline particles require careful handling and longer reconstitution, mid-to-advanced level injectors are best positioned to administer it.

Typical treatment areas include the chin, jawline, nasolabial folds, and full-face volume loss. Practitioners often choose it for facial contouring, structural support, and long-term volumizing plans, since results build over 6–8 weeks and last 24 months or more.

Preparation & Reconstitution

Practitioners prepare Proluma PLLA using 7cc of Sterile Water for Injection (SWFI) and 2cc of 2% lidocaine per vial.

1. Remove the flip-off or aluminum cap and disinfect the rubber stopper with an alcohol swab.
2. Using a sterile 18G needle and a 7mL syringe, slowly inject 7cc of SWFI into the vial.
3. Hold the vial upright and shake vigorously, or use a swirling mixer, for about 1 minute to dissolve the particles.
4. Let the vial rest for approximately 60 minutes to complete hydration.
5. Just before the procedure, inject 2cc of lidocaine using a sterile 18G needle for patient comfort.
6. Sanitize the stopper again, then withdraw the suspension with a sterile 1–3cc syringe and an 18G needle.
7. Switch to a 25G or 26G needle before performing the injection.

Injection Technique

Once the needle tip reaches the deep dermal layer, practitioners adjust the needle angle to 10–20 degrees and advance it within that plane, parallel to the skin’s surface. For nasolabial folds specifically, injections start at the base of the fold and follow its length, with radial injections added perpendicular to the initial path for fuller coverage.

• Inject 0.1–0.2ml per point, spaced 0.5–1cm apart
• Keep the suspension agitated throughout treatment to maintain consistency
• Massage the treated area gently after every 3–4 injections for even distribution
• Do not exceed 1ml of product per injection site

Post-Treatment Care

• Redness, swelling, and bruising can occur immediately after treatment and may last slightly longer than with PDLLA
• Massage the treated area in a circular motion for at least 2 minutes at the end of the session
• Apply an ice pack to reduce swelling or bruising, avoiding direct contact between ice and skin
• Avoid sun and UV exposure until any initial swelling and redness subside; recommend sunscreen to patients

Note: because of its deeper injection plane, only experienced or advanced-level medical aesthetics professionals should administer this product.

Frequently Asked Questions

What is Proluma PLLA?
Proluma PLLA is a CE-certified, high-purity poly-L-lactic acid collagen biostimulator that Genèse Labs designed for deep volume restoration and facial contouring.

How is Proluma PLLA different from Proluma PDLLA?
PLLA has a more crystalline structure and targets deeper collagen stimulation, so it suits advanced volume loss. PDLLA, by contrast, dissolves faster and suits earlier, more superficial correction.

How long do results last?
Results typically build over 6–8 weeks and last 24 months or more, since PLLA continues stimulating collagen over an extended period.

Who should administer Proluma PLLA?
Mid-to-advanced level injectors are best suited to it, given its deeper injection plane, longer reconstitution time, and post-care considerations.

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