Description

Regenovue PN — Polynucleotide & Hyaluronic Acid Skin Booster

Regenovue PN is a skin booster from NeoGenesis Co., Ltd. in South Korea, combining non-crosslinked hyaluronic acid (HA) with polynucleotide (PN) derived from salmon DNA. Because PN closely resembles human DNA in structure, it integrates smoothly into skin tissue. As a result, it supports tissue repair without triggering an immune response.

Specifically, Regenovue PN targets the fibroblast collagen network within the skin’s extracellular matrix, working at the superficial layer to improve hydration, elasticity, and overall texture.

At a Glance

HA Concentration	20mg/mL, non-crosslinked
PN Concentration	5mg/mL, salmon-derived
Duration	Up to 6 months
Manufacturer	NeoGenesis Co., Ltd., South Korea

Main Benefits

• PN and HA combined: pairs regenerative polynucleotide with hydrating, non-crosslinked HA
• High biocompatibility: PN’s structural similarity to human DNA supports smooth tissue integration
• Targets the extracellular matrix: supports fibroblast collagen network regeneration and elastin production
• Strengthens the skin barrier: improves resistance to environmental stress
• Supports tissue repair: aids cell proliferation and blood vessel restoration

What’s Inside

Polynucleotide (PN)	5mg/mL, derived from salmon sperm DNA
Hyaluronic Acid	20mg/mL, non-crosslinked (Sodium Hyaluronate)
Other Ingredients	Sodium chloride, disodium phosphate, sodium phosphate monobasic dihydrate
Manufacturer	NeoGenesis Co., Ltd., South Korea

No PN or PDRN injectable currently holds FDA approval for aesthetic use in the United States.

How Regenovue PN Works

PN and PDRN are related nucleotide polymers, both derived from salmon or trout DNA. Researchers generally distinguish them by chain length: PDRN refers to shorter chains, while PN refers to longer ones. Once introduced into the skin, these polymers act on adenosine A2A receptors. These receptors, in turn, support fibroblast proliferation and anti-inflammatory signaling.

Alongside this regenerative activity, the formula’s non-crosslinked HA draws in and holds moisture, supporting hydration and elasticity. Together, PN and HA work to restore the extracellular matrix and encourage new collagen and elastin production, supporting the skin’s overall structure and resilience.

Who Regenovue PN Suits

Practitioners recommend Regenovue PN for patients interested in:

• Improved skin hydration and elasticity
• Softening fine lines and superficial wrinkles
• Strengthening the skin’s natural barrier
• General skin tone and texture improvement

Treatment Areas

Face — applied to the superficial layer (epidermis)

Administration

A licensed practitioner administers Regenovue PN via mesotherapy or microneedling (MTS) technique, targeting the epidermal layer. Because the formula works at this superficial level, practitioners generally use it for skin quality improvement rather than deep structural correction.

Precautions

• For use by licensed medical or aesthetic professionals only
• Not recommended during pregnancy or breastfeeding
• Avoid in patients with known hypersensitivity to HA or PN
• Avoid in areas with active skin infection or inflammation

Storage & Handling

• Store at room temperature
• Single-use only — do not reuse or resterilize
• For professional use only, by qualified and trained practitioners

Frequently Asked Questions

What is Regenovue PN?
Regenovue PN is a skin booster from NeoGenesis. Specifically, it combines non-crosslinked HA (20mg/mL) with salmon-derived polynucleotide (5mg/mL) to support skin regeneration and hydration.

How is PN different from PDRN?
Both are nucleotide polymers derived from salmon or trout DNA. Researchers generally distinguish them by chain length, with PDRN referring to shorter chains and PN to longer ones.

How long do results last?
Generally, results last up to 6 months, depending on individual skin condition and treatment protocol.

How is Regenovue PN different from PN Plus?
NeoGenesis positions PN Plus as an enhanced version of the base Regenovue PN formula, built on the same PN and HA combination.

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