Description

Proluma RH Collagen — Recombinant Human Collagen Bio-Restorative Filler by Genèse Labs

Proluma RH Collagen is a next-generation bio-restorative filler developed by Genèse Labs in Paris, France. Specifically, it is the world’s first filler to combine Recombinant Human Collagen (Type I & III) with Succinic Acid, Polynucleotides, Hyaluronic Acid, and NAD+ in one synergistic formula.

As a result, Proluma RH Collagen supports multi-dimensional skin regeneration rather than hydration alone. Unlike single-collagen fillers, it addresses several aging pathways at once — energy loss, oxidative stress, dehydration, and impaired tissue repair. Moreover, it comes in a 2.5ml single-use vial.

Korea Filler Experts offers Proluma RH Collagen and ships it worldwide.

Key Benefits

• 3D facial contouring and lifting — Succinic Acid and Rh Collagen work together to activate fibroblasts and enhance extracellular matrix density
• Stretch mark reduction and firmness — dual collagen stimulation (Type I & III) strengthens skin structure while PN and HA restore elasticity
• Reduced pore visibility — restoring dermal structure helps pores appear minimized and skin texture smoother
• Increased skin density and elasticity — Collagen Type I & III combined with PN supports long-term extracellular matrix organization
• Antioxidant and anti-aging protection — Succinic Acid and NAD+ help defend against oxidative stress
• Deep hydration and vitality — Hyaluronic Acid provides long-lasting hydration while NAD+ supports cellular energy
• Support for scars and post-traumatic skin — Polynucleotides stimulate tissue regeneration and help remodel scar tissue
• Wrinkle reduction and smoothing — Rh Collagen fibers rebuild dermal structure while Polynucleotides support tissue repair

What’s Inside

Key Actives	Recombinant Human Collagen (Type I & III), Succinic Acid, NAD+, Polynucleotides (PN), High Molecular Weight Hyaluronic Acid
Intended Use	Bio-restorative filler for skin regeneration, firmness, and radiance
Packing Unit	2.5ml × 1 vial
Manufacturer	Genèse Labs, Paris, France (Proluma)

What Is Rh Collagen?

Recombinant Human Collagen (Rh Collagen) is produced through advanced biotechnology rather than animal extraction. Specifically, it is created using recombinant techniques that replicate the exact amino acid sequence of human collagen, achieving 99.9% similarity to the collagen naturally found in skin.

Because of this, Rh Collagen carries no risk of animal-related disease transmission and a very low risk of allergic reaction. Unlike older animal-derived collagen fillers, it does not need chemical crosslinking to remain stable, and it integrates smoothly into human tissue while directly stimulating fibroblasts.

Why Type I & III Together

Proluma RH Collagen is the first filler to provide both Type I and Type III recombinant collagen. In simple terms, Type I builds the structural framework of the skin, while Type III keeps that framework flexible. Together, they help restore the skin’s natural balance rather than structure alone.

• Type I Collagen: provides structural strength and dermal support, improves resilience, and enhances firmness and skin density
• Type III Collagen: maintains softness and a youthful appearance, promotes tissue repair, and supports elasticity and flexibility

How the Formula Works Together

Collagen alone restores structure, but skin aging involves several pathways at once. So Proluma RH Collagen pairs Rh Collagen with four bioactive ingredients to work across all of them.

Succinic Acid, a compound naturally involved in the Krebs cycle, helps stimulate fibroblast activity, supports cellular metabolism, and provides antioxidant protection. Meanwhile, NAD+ works to restore cellular energy balance and support DNA repair, helping protect against oxidative stress and premature aging.

Polynucleotides, derived from natural DNA fragments, promote fibroblast proliferation and extracellular matrix remodeling. As a result, they help improve hydration, elasticity, and tissue repair, and support scar remodeling. Finally, High Molecular Weight Hyaluronic Acid delivers long-lasting hydration and creates a favorable environment for fibroblast activity, stimulating keratinocyte proliferation and orienting collagen fibers as they form.

Who Is Proluma RH Collagen Suited For?

Practitioners use Proluma RH Collagen for patients who want to address:

• Fine lines, loss of firmness, and uneven skin texture
• Acne-related skin irregularities and stretch-mark-prone areas
• Nasolabial folds, marionette lines, and forehead or frown lines
• Crow’s feet, under-eye concerns, and cheek or midface laxity
• Neck (gular lines), hands, elbows, knees, and armpits

Treatment Areas

Face: Nasolabial folds · Crow’s feet · Forehead & frown lines · Marionette lines · Under-eye area · Cheeks & midface

Body: Neck (gular lines) · Hands · Elbows & knees · Armpits

Common application zones include the face, neck, décolleté, and hands, excluding the forehead and eye contour.

Recommended Treatment Course

• Typical dose: 2–2.5ml per session, depending on the treated area
• Initial course: two sessions spaced approximately 30 days apart
• Maintenance: follow-up sessions every 4 to 6 months

Improved hydration and smoothness may become noticeable shortly after application, with firmness and elasticity gradually improving over the following weeks.

What to Expect

Temporary redness or mild swelling can occur after treatment and typically resolves quickly. Because the formulation is animal-free and recombinant, it is designed for high skin tolerance. As with any injectable, only licensed and trained medical aesthetics professionals should administer this product.

Frequently Asked Questions

What is Proluma RH Collagen suitable for?
It supports skin appearance and quality, including fine lines, loss of firmness, uneven texture, acne-related irregularities, and stretch-mark-prone areas. Common zones include the face, neck, décolleté, and hands.

How much product is used per session?
On average, 2 to 2.5ml, depending on the area treated.

How often is it applied?
Typically, two initial sessions about 30 days apart, followed by maintenance applications every 4 to 6 months.

When are improvements visible?
Hydration and smoothness may be noticed shortly after application. However, firmness and elasticity tend to build gradually over the following weeks.

Are there any expected skin reactions?
Temporary redness or mild swelling may occur and usually resolves quickly, since the recombinant, animal-free formulation is designed for high skin tolerance.

What makes Proluma RH Collagen different?
Unlike single-collagen fillers, it pairs Type I & III Recombinant Human Collagen with Succinic Acid, Polynucleotides, Hyaluronic Acid, and NAD+ for broader, longer-lasting skin revitalization.

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