Description

AestheFill 200mg — PDLLA Collagen Biostimulator

AestheFill 200mg is a poly-D,L-lactic acid (PDLLA) collagen biostimulator from Regen Biotech Inc. in South Korea, carrying CE certification. Sculptra, by contrast, is built on poly-L-lactic acid (PLLA). AestheFill uses the D,L isomer of the material instead — a distinction that affects how the product behaves and degrades in tissue.

Rather than adding immediate physical volume, AestheFill works by activating fibroblasts to stimulate the body’s own collagen production. Results build gradually over a series of sessions. Even so, they also last considerably longer than typical HA fillers.

At a Glance

Total Composition	200mg per vial
Reconstitution	8mL sterile water
Duration	Up to 2 years following a full treatment series
Regulatory Status	CE certified
Manufacturer	Regen Biotech Inc., South Korea

Main Benefits

• Stimulates natural collagen production: works with the body’s own fibroblasts rather than just adding volume
• Long-lasting results: effects generally persist up to 2 years after a full treatment series
• Minimal downtime: most patients resume normal activities within 1–2 hours of treatment
• Fully biodegradable: breaks down into water and carbon dioxide, leaving no residue
• PDLLA-specific structure: differs from PLLA-based products like Sculptra in composition and degradation behavior

What’s Inside

Poly-D,L-Lactic Acid (PDLLA)	154mg
Carboxymethylcellulose (CMC)	46mg
Format	Lyophilized powder, reconstituted with 8mL sterile water
Packing	1 vial per box (200mg total)
Manufacturer	Regen Biotech Inc., South Korea

PDLLA as a raw material has held FDA GRAS (Generally Recognized As Safe) status since 1984. This refers to the material itself, not FDA approval of the finished AestheFill product, which is CE-certified rather than FDA-approved.

How AestheFill Works

Once reconstituted and injected, PDLLA particles trigger fibroblasts to produce new collagen and supporting tissue around the treated area. This process, called neocollagenesis, gradually restores lost volume and smooths wrinkles and folds from within. It works differently than the injected material itself providing bulk.

Over time, the PDLLA scaffold biodegrades into water and carbon dioxide, which the body clears naturally. Newly formed collagen replaces the material as it breaks down. Because of this, results continue to develop for weeks after each session and build further across a full treatment series.

Who AestheFill Suits

Practitioners recommend AestheFill for patients interested in:

• Correcting facial volume loss from natural aging
• Smoothing nasolabial folds, marionette lines, and other deep folds
• Restoring volume in sunken cheeks, temples, and under-eye hollows
• Patients seeking longer-lasting results than typical HA fillers provide

Treatment Areas

Forehead · Sunken cheeks · Cheekbones · Temples · Nasolabial folds · Marionette lines · Under-eye hollows · Chin creases and dimples

Preparation & Administration

Practitioners reconstitute the PDLLA powder with 8mL of sterile water before use, following standard aseptic technique. Administration typically uses an 18G cannula or needle, placed into the dermal or subdermal layers depending on the treatment area.

Recommended Treatment Course

Most patients complete an average of 3 injection sessions, spaced 4 to 6 weeks apart, to build collagen progressively. Some initial swelling right after treatment can look like an instant result. However, this settles within a few days as the true collagen-stimulating process gets underway. Once the full series is complete, a single maintenance session roughly once a year helps sustain results.

Post-Treatment Care

• Avoid strenuous activity, excessive sun exposure, and extreme temperatures for 24 to 48 hours after treatment
• Avoid touching the injection sites to reduce infection risk
• Avoid saunas, steam rooms, and swimming pools for a period following treatment

Precautions

• For use by a licensed medical professional only
• Not recommended during pregnancy or breastfeeding
• Avoid in patients with active skin infection or inflammation at the injection site
• Discuss any history of keloid scarring or autoimmune conditions before treatment

Storage & Handling

• Store at room temperature, away from direct light
• Reconstitute shortly before use, following manufacturer instructions
• Single-use only — do not reuse or resterilize

Frequently Asked Questions

What is AestheFill 200mg?
AestheFill is a PDLLA-based collagen biostimulator from Regen Biotech, designed to restore facial volume and smooth wrinkles by stimulating the body’s own collagen production.

Is AestheFill the same as Sculptra?
No. Sculptra is made from PLLA (poly-L-lactic acid). AestheFill, on the other hand, uses PDLLA (poly-D,L-lactic acid), a related but chemically distinct material with different degradation behavior.

Is AestheFill FDA-approved?
The finished product carries CE certification rather than FDA approval. PDLLA as a raw material has held FDA GRAS status since 1984, but that applies to the material, not the finished device.

How long do results last?
Results generally last up to 2 years following a complete treatment series, with an annual maintenance session recommended to sustain them.

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