Description

Nabota 100UI — Botulinum Toxin Type A

Nabota 100UI is a botulinum toxin type A product from Daewoong Pharmaceutical, a South Korean biopharmaceutical company with more than 30 years of experience. Nabota holds a distinctive place among Asian botulinum toxins: it earned the first approval from the U.S. FDA, the European Medicines Agency, and Health Canada among toxins in its category.

In the United States, Daewoong markets this same formulation under the brand name Jeuveau, through its partner Evolus Inc. Jeuveau received FDA approval in February 2019. Notably, it remains the only botulinum toxin in the U.S. market approved exclusively for aesthetic use.

At a Glance

Units per Vial	100 units
Onset	3–5 days
Duration	3–4 months
Purity	>98.7% (Hi-Pure Technology)
Regulatory Status	FDA, EMA, Health Canada approved (as Jeuveau)

Main Benefits

• Smoother, younger-looking skin: relaxes the muscles behind frown lines, forehead wrinkles, and crow’s feet
• Softer facial expressions: reduces excessive muscle contraction without producing a “frozen” look
• Lifting and contouring: used strategically, it can help lift the brow or contour the jawline
• Muscle tension relief: in therapeutic use, it eases spasms and tightness in areas like the neck, eyelids, or jaw

What’s Inside

Active Ingredient	Clostridium botulinum toxin type A — 100 units
Stabilizer	Human serum albumin — 0.5mg
Additive	Sodium chloride — 0.9mg
Purity	Greater than 98.7%, via Hi-Pure Technology
Format	Vacuum-dried powder, single-dose vial
Shelf Life	36 months
Manufacturer	Daewoong Pharmaceutical Co., Ltd., South Korea

Packaging and included accessories (syringes, saline, gloves) vary by supplier — check your specific listing for exact kit contents.

How Nabota Is Made

Daewoong produces the toxin through controlled fermentation of Clostridium botulinum. Then, the company extracts and purifies it using their patented Hi-Pure Technology. This step reduces impurities and non-essential proteins that lower-purity formulations often retain.

This purity matters clinically. Accessory proteins in less-purified toxins can trigger immune recognition over repeated use. Consequently, this may lead to neutralizing antibody formation and reduced effectiveness over time. Because Nabota’s purification process specifically targets this risk, practitioners often consider it suitable for patients who have used other botulinum toxins without developing resistance.

What Nabota Is Made Of

Clostridium Botulinum Toxin Type A	The purified neurotoxin protein that temporarily relaxes targeted muscles
Human Serum Albumin	A stabilizing protein that helps maintain effectiveness during storage and after reconstitution
Sodium Chloride	An isotonic agent that keeps the solution compatible with the body when injected

How Nabota Works

Nabota works by temporarily blocking the release of acetylcholine, the chemical messenger responsible for muscle contraction, at the neuromuscular junction. Once injected into a target muscle, this reduces the muscle’s activity. As a result, dynamic wrinkles soften, and certain spasm-related conditions ease. Because the effect stays localized to the treated muscle, however, untreated areas remain unaffected.

Indications

Practitioners use Nabota 100UI for both cosmetic and therapeutic purposes:

• Facial rejuvenation: frown lines, forehead lines, and crow’s feet
• Facial contouring: masseter reduction for jaw slimming, subtle brow lifting
• Muscle-related conditions: blepharospasm, cervical dystonia, and spasticity, including in children with cerebral palsy, under professional supervision

Treatment Areas

Face: Forehead · Glabella · Crow’s feet · Bunny lines (nose) · Masseter (jaw) · Chin · Perioral area · Eyebrows

Body: Neck (platysmal bands) · Shoulders and upper back · Lower limbs (spasticity, including pediatric cases) · Other localized muscle spasm sites, depending on medical evaluation

Preparation & Dilution

Practitioners reconstitute Nabota with non-preserved, sterile 0.9% saline. Because the powder is compressed under vacuum, the vial can look nearly empty before reconstitution. This is normal, and the full dose remains present.

Saline Added (100U vial)	Resulting Concentration
1.0mL	10.0 units per 0.1mL
2.0mL	5.0 units per 0.1mL
2.5mL	4.0 units per 0.1mL
4.0mL	2.5 units per 0.1mL
8.0mL	1.25 units per 0.1mL

1. Draw the required saline volume with a sterile syringe
2. Insert the needle and slowly inject the saline into the vial, which contains a vacuum
3. Inject slowly to avoid forming bubbles
4. Gently swirl (do not shake) until the solution is completely clear
5. Record the date and time of reconstitution
6. Store refrigerated at 2–8°C and use within 24 hours

Dosage & Injection Technique

A common reference dilution is 2.5mL saline per 100-unit vial, yielding 4 units per 0.1mL. However, dosing depends on the treatment area, muscle strength, and patient anatomy — a qualified practitioner should determine the exact plan. Reference ranges include:

Area	Typical Dose	Injection Points
Glabellar lines	20 units total	5 points (2 per corrugator, 1 in procerus)
Forehead lines	10–20 units	Varies with muscle strength
Crow’s feet	12 units per side	3 points per side
Bunny lines	4–6 units	Divided between both sides
Masseter (jaw slimming)	25–50 units per side	Depends on muscle thickness

• Use a fine-gauge needle, typically 30–32G
• Inject at roughly a 90° angle for superficial muscles, or around 45° for deeper muscles
• Avoid injecting close to the levator palpebrae superioris to reduce the risk of eyelid drooping (ptosis)
• Inject gently, without excessive pressure, to limit bruising and diffusion into unintended areas

Post-Treatment Care

• Avoid rubbing or massaging the treated area for at least 24 hours
• Avoid strenuous exercise, heat exposure, and alcohol for 24 hours
• Avoid lying down for several hours after treatment
• Mild bruising, redness, or swelling can occur and typically resolves within a few days

Onset & Duration

Initial improvements often appear within 3 to 5 days, with the full effect developing over 7 to 14 days. Results generally last 3 to 4 months. Many patients see meaningful improvement from a single session. Even so, most return for maintenance treatment every 3 to 4 months to sustain results over time.

Precautions

• For use by licensed medical professionals only
• Contraindicated in patients with neuromuscular disorders, such as myasthenia gravis, ALS, or Lambert-Eaton syndrome
• Contraindicated during pregnancy or breastfeeding
• Avoid in patients with active skin infections or bleeding disorders
• Common side effects include injection site redness, swelling, bruising, temporary muscle weakness, and, rarely, ptosis

Storage & Handling

• Store refrigerated at 2–8°C
• Do not freeze
• Use within 24 hours after reconstitution; some data suggests stability up to 5 weeks when properly refrigerated, though 24-hour use is the standard recommendation

Botulinum toxin type A is a prescription medical product for use by licensed healthcare professionals only.

Frequently Asked Questions

What is Nabota 100UI used for?
Practitioners use it to reduce facial wrinkles such as frown lines, forehead lines, and crow’s feet, and to treat muscle-related conditions like blepharospasm, cervical dystonia, and spasticity in children with cerebral palsy.

How is Nabota the same as Jeuveau?
Jeuveau is the brand name Daewoong’s partner Evolus uses to market this same formulation in the United States, where it received FDA approval in 2019.

Why does the vial look empty?
Because Nabota’s freeze-dried powder is compressed under vacuum, very little is visible at the bottom of the vial. The full 100-unit dose remains present and dissolves completely once reconstituted.

Can Nabota be used for jaw slimming?
Yes. Practitioners commonly inject it into the masseter muscle to reduce jaw muscle bulk for a slimmer facial contour, typically at 25–50 units per side.

How long do results last?
Results generally last 3 to 4 months. Because of this, practitioners typically recommend maintenance sessions on that same schedule to sustain the effect.

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