Description

Regenovue PN Plus — Enhanced Polynucleotide Skin Rejuvenation

Regenovue PN Plus is an enhanced skin rejuvenation formula from NeoGenesis Co., Ltd. in South Korea. It builds on the same polynucleotide (PN) and hyaluronic acid (HA) combination found in the base Regenovue PN formula. This version is positioned for deeper regeneration of the fibroblast collagen network and stronger overall revitalization.

Because PN closely resembles human DNA in structure, it integrates smoothly into skin tissue. PN Plus builds on this foundation to deliver more pronounced improvements in tissue repair, cell proliferation, and vascular renewal.

At a Glance

Core Actives	Polynucleotide (PN) + non-crosslinked Hyaluronic Acid
PN Source	Salmon sperm DNA
Manufacturer	NeoGenesis Co., Ltd., South Korea

Specific concentration figures for the “Plus” formulation weren’t consistently available across sources — confirm exact specs with your supplier if precise dosing details are needed.

Main Benefits

• Enhanced fibroblast regeneration: targets deeper rebuilding of the collagen network within the extracellular matrix
• High biocompatibility: PN’s structural similarity to human DNA supports smooth tissue integration
• Vascular renewal support: aids in restoring blood vessel function alongside tissue repair
• Stronger barrier support: reinforces the skin’s resistance to environmental stress
• Improved tone and texture: supports a more radiant, youthful complexion

What’s Inside

Polynucleotide (PN)	Derived from salmon sperm DNA
Hyaluronic Acid	Non-crosslinked
Manufacturer	NeoGenesis Co., Ltd., South Korea

No PN or PDRN injectable currently holds FDA approval for aesthetic use in the United States.

How Regenovue PN Plus Works

PN and PDRN are related nucleotide polymers, both derived from salmon or trout DNA, generally distinguished by chain length. Once introduced into the skin, these polymers act on adenosine A2A receptors. This supports fibroblast proliferation and anti-inflammatory signaling.

PN Plus builds on the same mechanism as the standard formula. Because of this, it works to restore the extracellular matrix, encourage new collagen and elastin production, and support blood vessel renewal. This combination targets deeper skin layers than a standard hydration-focused treatment, aiming for more comprehensive tissue-level improvement.

Who Regenovue PN Plus Suits

Practitioners recommend Regenovue PN Plus for patients interested in:

• More pronounced skin regeneration than the standard PN formula provides
• Deeper collagen network rebuilding
• Improved hydration, elasticity, and skin barrier function
• General skin tone and texture revitalization

Treatment Areas

Face — applied to the superficial layer (epidermis)

Administration

A licensed practitioner administers Regenovue PN Plus via mesotherapy or microneedling (MTS) technique, targeting the epidermal layer. As with the standard formula, this delivery method suits general skin quality improvement rather than deep structural correction.

Precautions

• For use by licensed medical or aesthetic professionals only
• Not recommended during pregnancy or breastfeeding
• Avoid in patients with known hypersensitivity to HA or PN
• Avoid in areas with active skin infection or inflammation

Storage & Handling

• Store at room temperature
• Single-use only — do not reuse or resterilize
• For professional use only, by qualified and trained practitioners

Frequently Asked Questions

What is Regenovue PN Plus?
Regenovue PN Plus is an enhanced version of NeoGenesis’s Regenovue PN skin booster, built on the same salmon-derived polynucleotide and HA combination for deeper skin regeneration.

How is PN Plus different from the standard Regenovue PN?
PN Plus is positioned for more pronounced regeneration of the fibroblast collagen network, while the standard formula focuses more broadly on hydration and general skin quality.

How does PN support skin regeneration?
PN acts on adenosine A2A receptors in the skin, which are associated with fibroblast proliferation and anti-inflammatory signaling, supporting tissue repair and collagen network restoration.

Is Regenovue PN Plus FDA-approved?
No. Like other PN and PDRN injectables, it does not currently hold FDA approval for aesthetic use in the United States.

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