Description

Exoxe — Amniotic Stem Cell-Derived Exosome Skin Booster

Exoxe is a two-part exosome skin treatment from Regenbogen, manufactured by Nature Intro Co., Ltd. in South Korea. Most Korean exosome products use adipose-derived stem cell sources. Exoxe works differently: it uses exosomes derived from amniotic stem cells, which the manufacturer describes as the youngest mesenchymal stem cell type available.

The system combines a lyophilized exosome powder with a hyaluronic acid solution, mixed together before use. Exoxe falls into the exosome product category. Because of this, it also carries the same serious regulatory considerations affecting this entire class of treatments, discussed in detail below.

At a Glance

Core Ingredient	Amniotic stem cell-derived exosomes
Format	2-part system: 50mg lyophilized powder + 5mL HA solution
Manufacturer	Regenbogen (Nature Intro Co., Ltd.), South Korea

Main Benefits

• Amniotic stem cell source: a differentiator from the adipose-derived exosomes used in most competing products
• Combined with hyaluronic acid: pairs regenerative exosome content with direct hydration
• Mineral-enriched formula: includes 6 minerals supporting overall skin health
• High particle concentration: the manufacturer states billions of extracellular vesicle particles per treatment

What’s Inside

Exosomes	Derived from amniotic stem cells
Hyaluronic Acid	Provides hydration and moisture retention
Minerals	6 types, supporting skin health and vitality
Manufacturer	Regenbogen (Nature Intro Co., Ltd.), South Korea

Important Regulatory Context

The US FDA has not approved exosome-based products for any use, whether derived from adipose tissue, amniotic tissue, or other stem cell sources. The FDA issued a formal Public Safety Notification on exosome products after multiple reports of serious adverse events in treated patients. The agency has also sent warning letters to companies selling exosome products, including as recently as 2025.

Peer-reviewed case reports have also documented serious complications from exosome injections performed at aesthetic clinics. These include a published case of skin necrosis following dermal exosome injection at a Korean clinic. Because of this, practitioners and buyers should independently verify the current legal status of exosome-based products in their own country or state before purchase, marketing, or use.

How Exoxe Works

Exosomes are small vesicles that cells naturally release to communicate with surrounding tissue, carrying proteins, nucleic acids, and lipids. Regenbogen sources Exoxe’s exosomes from amniotic stem cells. The manufacturer positions this source as offering stronger regenerative signaling than exosomes derived from more mature cell sources.

Once combined with the hyaluronic acid solution and applied, the formula is intended to deliver these regenerative signals to skin cells alongside direct hydration from the HA component. The manufacturer states this combination supports collagen production, tissue repair, and improved skin tone. However, independent, controlled clinical evidence for these specific claims is limited.

Who Exoxe Suits

Where legally permitted, practitioners have marketed Exoxe toward patients interested in:

• Overall skin brightness and radiance
• Fine lines and wrinkle reduction
• Post-procedure skin healing support
• General skin regeneration and quality improvement

Treatment Areas

Face

Administration

The lyophilized powder and HA solution are mixed together immediately before use. Depending on the intended market and practitioner preference, practitioners apply the mixture topically to cleansed, dry skin or deliver it via microneedling or injection. The manufacturer recommends using the full vial promptly once opened.

Precautions

• Confirm current local and national regulatory status before purchase or use — exosome products are not FDA-approved, and some jurisdictions restrict or prohibit them
• For use by licensed medical or aesthetic professionals only, where legally permitted
• Not recommended during pregnancy or breastfeeding
• Avoid in patients with known hypersensitivity to any formula component

Storage & Handling

• Store as directed by the manufacturer, protected from light
• Use promptly once opened — do not store reconstituted product for later use
• Single-use only — do not reuse or resterilize

Frequently Asked Questions

What is Exoxe?
Exoxe is a two-part exosome skin treatment from Regenbogen, combining amniotic stem cell-derived exosomes with a hyaluronic acid solution for skin regeneration and hydration.

Is Exoxe FDA-approved?
No. Exosome-based products are not FDA-approved for any use. The FDA has issued safety notifications and warning letters for this product category. In addition, peer-reviewed case reports have documented serious adverse events from exosome injections.

How is Exoxe different from other Korean exosome products?
Exoxe uses exosomes derived from amniotic stem cells, while many competing products, including ExoCoBio’s ASCE+ line, use adipose-derived or other stem cell sources.

Is Exoxe applied topically or injected?
Sources describe both approaches. Confirm the intended application method with your supplier and verify it’s consistent with local regulations before use.

---

Buy Exoxe online from Korea Filler Experts, a trusted wholesale supplier of premium aesthetic products. We ship worldwide.