Rejuran Healer Black
High-concentration polynucleotide · 2% PN, salmon-derived · PharmaResearch, South Korea. CE certified. The intensive formula in the Rejuran line.
Original price was: $249.90.$199.90Current price is: $199.90.
Rejuran Black Healer is a high-concentration PDRN skin regenerator from PharmaResearch, formulated for damaged skin barriers, enlarged pores, and pronounced signs of aging. It carries CE certification.
Professional use only. This product is intended for administration by licensed healthcare practitioners trained in the relevant anatomy and injection technique. By ordering you confirm you are authorised to purchase and handle products of this class in your jurisdiction. Availability and permitted use vary by country — please verify local regulations before ordering.
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The high-concentration formula in the Rejuran range
Rejuran Healer Black is PharmaResearch’s intensive polynucleotide formula — a higher concentration of the same salmon-derived active that runs through the whole Rejuran line, at a stated 2% PN with purity above 99%.
Concentration is the entire proposition here. Where the standard Healer suits general skin-quality work, Black is chosen when the skin presenting in front of you needs more: thinned, compromised, visibly photoaged skin where a lighter formula has been tried and under-delivered.
That extra concentration comes with a trade-off worth naming at consultation. A denser formula means more pronounced papules after injection and a less comfortable session than the lidocaine-containing HB. Patients choosing Black should know they are buying intensity, not comfort.
The highest-concentration general formula in the line — Rejuran S is denser still, but is scar-specific.
PharmaResearch's stated figure for the purified salmon-derived polymer.
Chosen where standard-concentration PN has been tried and the response was insufficient.
No lidocaine, higher density. Expect more pronounced papules than with HB or Skinbooster.
Why practitioners choose Rejuran Healer Black
Not a repackaging exercise — Black carries meaningfully more PN per millilitre than standard Healer, which is the reason to reach for it.
Where a patient has completed a standard PN course with a modest result, moving up in concentration is the logical next step before changing modality.
Above 99%, which matters for a biologically derived polymer where process residues are the plausible source of unwanted reactions.
Carries CE certification. Confirm what that permits in your own market, since CE marking is not a global authorisation.
Treatment areas and indications
Areas commonly treated with high-concentration PN. Permitted indications vary by market — work from the manufacturer’s instructions for use and the regulations where you practise.
Visibly weathered skin with loss of dermal density, where a standard-concentration course has delivered less than hoped. The clearest case for moving up to Black.
Skin that is reactive, thin or in poor condition, where supporting the dermal matrix is the goal. PN supports the skin’s own matrix production rather than adding anything that stays.
Improving the firmness of the dermis around follicular openings, which reduces how much they appear to gape. Not a reduction in pore size itself — worth describing precisely.
Patients who completed a standard-concentration course with a modest result. Increasing concentration is the logical next step before changing modality entirely.
Skin boosters are injectable medical products. Which indications are permitted, and what training is required, is determined by the regulatory framework where you practise. Korea Filler Experts supplies the product; nothing here is a recommendation to treat any medical condition, and nothing here substitutes for manufacturer training.
What is inside Rejuran Healer Black
| Active | Polynucleotide (PN), salmon-derived |
| Concentration | 2% (manufacturer stated) |
| Purity | Greater than 99% (manufacturer stated) |
| Anaesthetic | None — consider topical anaesthesia |
| Typical course | 3–4 sessions, 2–4 weeks apart |
| Review interval | Commonly 6–12 months after a completed course |
| Route | Intradermal / superficial subdermal injection |
| Regulatory | CE certified |
| Manufacturer | PharmaResearch, South Korea |
| SKU | 08032 |
Before you order
- Check the lot number and expiry on the carton against the vial.
- We do not dispatch stock with under 6 months of shelf life remaining unless agreed in advance.
- Store as stated on the carton. Do not freeze, and protect from light.
- Plan topical anaesthetic — unlike HB, there is no lidocaine in this formula.
Ask us about volume pricing on this line. Tiered rates are set on most Rejuran products; if you are ordering several units of Black, contact us before you check out.
What each component does
What concentration actually changes
More polynucleotide per millilitre means more active delivered per injection point, and a denser, more viscous solution. Both have consequences:
- More active per point — a stronger stimulus to the dermis at each site.
- More viscous solution — slower to inject, more resistance through a fine needle, and more pronounced papules that take longer to settle.
What we would not tell you is that higher concentration reliably produces a proportionally better clinical result. Dose-response in PN skin boosting is not well characterised in published head-to-head work, and the sensible reading is that concentration is one variable among several — alongside session count, injection density and the patient’s own skin.
On enlarged pores
Pore appearance is frequently listed as an indication for this product, and it needs qualifying. Pore size is largely structural, determined by follicular anatomy and sebaceous output. A polynucleotide booster does not shrink the follicular opening.
What it can do is improve the density and firmness of the surrounding dermis, which reduces how much a pore appears to gape. That is a real and visible effect, but it is a different claim from pore reduction — and describing it accurately will serve you better at the review appointment.
PN or PDRN?
Both terms describe purified DNA polymers from salmon or trout and are used interchangeably across most of the market. The technical distinction is molecular weight — PDRN generally shorter-chain, PN longer. A 2025 review proposed a 1500 kDa boundary, but that is a naming convention rather than a regulatory standard, and published ranges overlap. We have found no controlled head-to-head study establishing that one outperforms the other.
How it works
Polynucleotides are purified DNA polymers, in this case from salmon. Injected into the dermis they act in two ways.
As a signal: the working mechanism is understood to involve adenosine A2A receptor activation, which supports fibroblast activity and collagen synthesis and modulates the local inflammatory environment. This is why PN is described as regenerative rather than volumising — it prompts the skin’s own matrix production rather than adding bulk.
As a scaffold: the polymer forms a hydrophilic three-dimensional structure in the dermis that holds water and provides a physical framework while that matrix response develops.
Concentration affects how much of that stimulus is delivered per injection point, and how viscous the solution is to work with. It does not change the mechanism itself.
How to use Rejuran Healer Black
Reference information for licensed practitioners. Technique, depth and dose must follow the manufacturer’s instructions for use and the regulations applying where you practise.
Step by step
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Assess whether concentration is the right lever
Black is for skin that needs more than standard PN delivers. If a patient has not yet tried a standard-concentration course, starting here adds discomfort without a clear reason.
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Plan anaesthesia properly
No lidocaine in this formula and a denser solution to deliver. Topical anaesthetic applied with adequate dwell time is not optional for a comfortable full-face session.
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Cleanse thoroughly
Standard antisepsis across the whole treatment area — you will be creating many entry points.
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Allow for the viscosity
A denser solution needs steadier pressure and a slower delivery. Rushing produces uneven aliquots and a patchier result.
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Inject into the correct plane
Intradermal or superficial subdermal. Too deep wastes the product; too superficial makes already-prominent papules worse and slower to settle.
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Set papule expectations explicitly
Papules are more pronounced with Black than with lighter formulas and may take longer than 72 hours to settle fully. Say so before treating, and schedule accordingly.
Administration notes
A course, not a single treatment. PN boosters work cumulatively over three to four sessions, two to four weeks apart. The “6 to 12 months” figure refers to results holding after a completed course — not after one vial. At this price point in particular, the patient needs to understand the total commitment before session one.
Plan the social calendar around it. More pronounced papules mean Black is a poor choice two days before an event. A patient treated on a Thursday for a Saturday wedding will not thank you.
- Single use. One vial, one patient. Discard any remainder.
- Avoid treating over active infection, inflamed skin or active acne lesions.
- Ask directly about fish allergy — the active is salmon-derived.
- Dispose of needles into a sharps container per local clinical waste requirements.
After treatment
- Papules at injection points are expected, more pronounced than with lighter formulas, and may take up to 72 hours or longer to settle
- Mild redness, swelling and pinpoint bruising are common for one to three days
- No make-up for 12 hours; keep the area clean
- Avoid saunas, steam rooms, swimming and strenuous exercise for 48 hours
- Avoid active skincare — retinoids, acids, vitamin C — for several days
- Sun protection, and no sunbeds, while the skin settles
- Book the next session in the course before the patient leaves
Storing and handling Rejuran Healer Black
Store as stated on the carton and in the manufacturer’s insert, protected from light. Do not freeze — freezing damages the polynucleotide structure.
Allow the vial to reach room temperature. A cold high-concentration formula is appreciably harder to deliver evenly and more uncomfortable for the patient.
Single patient, single session. Do not retain an opened vial — there is no preservative system intended to support that.
Do not use if the solution is discoloured or contains visible particles, if the expiry date has passed, or if the packaging seal is broken. Dispose of unused product and used vials as clinical waste in line with local requirements.
What's included with Rejuran Healer Black
Needles, syringes and topical anaesthetic are not supplied — and topical anaesthetic is strongly advised with this formula, as it contains no lidocaine. Plan a full course when ordering.
Rejuran Healer Black — frequently asked questions
What is Rejuran Healer Black?
The high-concentration polynucleotide formula in PharmaResearch’s Rejuran line — a stated 2% PN with purity above 99%, derived from salmon DNA. It is injected intradermally across the treatment area by a licensed practitioner.
How is it different from standard Rejuran Healer?
Concentration. Black carries meaningfully more polynucleotide per millilitre than the standard formula.
In practice that means a stronger stimulus per injection point, a denser solution to deliver, and more pronounced papules afterwards. It is chosen for skin that needs more than a standard course delivered — not as a default upgrade.
Does higher concentration mean a proportionally better result?
Not demonstrably, and we would rather be straight about that. Dose-response for PN skin boosting is not well characterised in published head-to-head work.
Concentration is one variable among several — session count, injection density and the patient’s own skin all matter. Treating it as the single determinant of outcome would be overstating what is known.
Will it reduce enlarged pores?
Not by shrinking them. Pore size is largely structural — follicular anatomy and sebaceous output — and no injectable booster changes that.
What improves is the density and firmness of the surrounding dermis, which reduces how much a pore appears to gape. That is a real visible effect, but it is a different claim from pore reduction, and describing it accurately serves you better at review.
Is it more painful than other Rejuran formulas?
Yes. There is no lidocaine in this formula and the solution is denser than HB or Skinbooster. Plan topical anaesthetic with adequate dwell time.
Papules afterwards are also more pronounced and slower to settle. Patients should hear both points before treatment.
How long do results last?
The usual figure is six to twelve months — but that refers to results holding after a **completed course** of three to four sessions, not after a single vial. At this price point, make sure the patient understands the full commitment before session one.
What does CE certified mean here?
The product carries CE certification. That is a European conformity marking, not a global authorisation — it does not establish what you are permitted to purchase or administer in your own market.
Check your national requirements before ordering.
Is the salmon origin a concern for patients with fish allergy?
Ask about it directly. The active is purified from salmon DNA, and while the purification process removes protein, a stated fish allergy is a reason for caution and a conversation rather than an assumption.
PharmaResearch states purity above 99%; that is reassuring but not a substitute for taking a history.
Can I use it around the eyes?
Rejuran I is the formula designed for the periorbital area — lower viscosity, formulated for thin skin where a dense formula leaves visible, persistent bumps.
Using Black there is not what it was designed for.
Who can buy and use this product?
Injectable skin boosters are for administration by licensed healthcare practitioners trained in the relevant technique. We supply to professionals qualified to purchase and administer products of this class in their jurisdiction, and do not sell to consumers.
Customer Reviews
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Had a few questions about the expiration date before ordering. Customer service was quick to help.
Not my first box and definitely won't be my last. A personal favorite.
Not the most budget-friendly option, but I'm comfortable paying more for something I know.
I've been loyal to this product for a while now. Still one of my top picks.
Pricey? Yes. Do I regret ordering it? Nope.
Not cheap, but I can see why people are willing to pay for it. I'd purchase again.
I was hesitant because of the price, but I'm happy I tried it.
I understand the repeat buyers now. Not cheap, but I'd buy it again.
Took me forever to decide whether to buy this one. No regrets so far.
I almost scheduled an extra treatment too quickly because I was impatient. Glad I waited. Once my skin had enough time to settle, the improvement became much clearer.
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