Description

Nabota 200UI — Botulinum Toxin Type A

Nabota 200UI is a botulinum toxin type A product from Daewoong Pharmaceutical, a South Korean biopharmaceutical company with more than 30 years of experience. This vial delivers double the toxin content of the standard 100-unit option, suiting larger treatment areas or multiple zones in a single session.

Nabota holds a distinctive place among Asian botulinum toxins: it was the first to receive approval from the U.S. FDA, the European Medicines Agency, and Health Canada. In the United States, Daewoong markets this same formulation under the brand name Jeuveau, through its partner Evolus Inc.

At a Glance

Units per Vial	200 units
Onset	2–3 days
Duration	3–4 months
Purity	>98.7% (Hi-Pure Technology)
Regulatory Status	FDA, EMA, Health Canada approved (as Jeuveau)

Key Benefits

• Delivers 200 units per vial, reducing the need for multiple vials in larger sessions
• Backed by FDA, EMA, and Health Canada approval — a first among Asian botulinum toxins
• Produced using patented Hi-Pure Technology for high purity and minimal impurities
• Free from preservatives, supporting a hypoallergenic profile
• Delivers fast onset, with visible results often within 2 to 3 days

What’s Inside

Active Ingredient	Clostridium botulinum toxin type A — 200 units
Stabilizer	Human serum albumin
Additive	Sodium chloride
Format	Vacuum-dried powder, single-dose vial
Shelf Life	36 months
Manufacturer	Daewoong Pharmaceutical Co., Ltd., South Korea

How Nabota Is Made

Daewoong produces the toxin through a fermentation process, then extracts and purifies it using their patented Hi-Pure Technology. This step removes accessory proteins and impurities that lower-purity formulations often retain. The result is a formulation containing more than 98% of the 900 kDa botulinum toxin complex, closely resembling the structure of the original Botox.

This purity matters clinically, not just as a marketing point. Accessory proteins in less-purified toxins can trigger immune recognition over repeated use, which may lead to neutralizing antibody formation and reduced effectiveness over time. Nabota’s purification process is designed to reduce this risk.

How Nabota Works

Once injected into a target muscle, botulinum toxin type A blocks the nerve signals responsible for muscle contraction. This temporarily reduces the muscle’s activity. As a result, dynamic wrinkles caused by repeated facial movement soften, and overactive muscles relax.

Treatment Areas & Typical Dosing

Dosing varies by treatment area and patient anatomy. A qualified practitioner should always determine the exact dose. The figures below reflect commonly cited reference ranges:

Area	Typical Dose	Injection Points
Glabellar lines (frown lines)	20 units	5 points
Forehead lines	10–20 units	4–6 points
Crow’s feet	12 units per side	3 points per side
Bunny lines (nose)	4–6 units	1–2 points
Masseter (jaw slimming)	25–50 units per side	2–3 points per side

Injection Technique

• Practitioners typically use a fine 30–32G needle
• For superficial muscles (forehead, crow’s feet), inject at roughly a 90° angle
• For deeper muscles (masseter, neck), a shallower angle around 45° is more common
• Aspirate before injecting and avoid vascular areas

Preparation & Dilution

Practitioners reconstitute Nabota with preservative-free 0.9% saline. Because the powder is compressed under vacuum, the vial can look nearly empty before reconstitution — this is normal. The table below shows common dilution ratios for the 200-unit vial:

Saline Added	Resulting Concentration
2.5mL	8 units per 0.1mL
4mL	5 units per 0.1mL
5mL	4 units per 0.1mL
8mL	2.5 units per 0.1mL
10mL	2 units per 0.1mL

Once reconstituted, use the solution within 24 hours and store it refrigerated at 2–8°C in the meantime.

Onset & Duration

Initial effects typically appear within 2 to 3 days, with peak results developing over 1 to 2 weeks. Results generally last 3 to 4 months, depending on the treatment area and individual patient factors. Most patients return for maintenance sessions every 3 to 4 months to sustain results.

Post-Treatment Care

• Avoid massaging or rubbing the treated area for at least 24 hours
• Avoid strenuous exercise, heat exposure, and alcohol for 24 hours
• Mild bruising, redness, or swelling at injection sites can occur and typically resolves within a few days
• Avoid lying down for 4 hours after treatment

Indications

Practitioners use Nabota 200UI for cosmetic applications, including glabellar lines, forehead lines, crow’s feet, bunny lines, and masseter reduction for jaw slimming, often combining multiple areas in one session given the higher unit count. Outside the United States, where broader indications are approved, practitioners also use it for spasticity following stroke, overactive bladder syndrome, focal hyperhidrosis, and other neuromuscular conditions.

Precautions

• For use by licensed medical professionals only
• Contraindicated in patients with neuromuscular disorders, such as myasthenia gravis, ALS, or Lambert-Eaton syndrome
• Contraindicated during pregnancy or breastfeeding
• Avoid in patients with active skin infections or bleeding disorders
• Common side effects include injection site redness, swelling, bruising, temporary muscle weakness, and, rarely, ptosis

Storage & Handling

• Store refrigerated at 2–8°C
• Do not freeze
• Use within 24 hours after reconstitution

Botulinum toxin type A is a prescription medical product for use by licensed healthcare professionals only.

Frequently Asked Questions

What is Nabota 200UI?
Nabota 200UI is a high-purity botulinum toxin type A product from Daewoong Pharmaceutical, offering double the standard unit count for larger treatment sessions.

Who is the 200UI vial best suited for?
Practitioners treating larger areas, multiple facial zones (such as combining glabellar lines with masseter reduction), or higher patient volumes often prefer it, since one vial can cover more treatment area than the 100-unit option.

Why does the vial look empty?
Nabota’s freeze-dried powder is compressed under vacuum, so very little is visible at the bottom of the vial. The full 200-unit dose is present and dissolves completely once reconstituted with saline.

Is Nabota the same as Jeuveau?
Yes. Jeuveau is the brand name Daewoong’s partner Evolus uses to market this same formulation in the United States.

How is Nabota 200UI different from the 100UI version?
Both share the same formulation and manufacturer. The 200UI vial simply contains double the toxin units, reducing the need for multiple vials in larger sessions.

Can Nabota be used for jaw slimming?
Yes. Injected into the masseter muscle, Nabota is commonly used to reduce jaw muscle bulk for a slimmer facial contour, typically at 25–50 units per side.

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