Description

Botulax 200UI — High-Purity Botulinum Toxin Type A

Botulax 200UI is a botulinum toxin type A product from Hugel, Inc., one of South Korea’s largest and most established pharmaceutical manufacturers. This vial delivers double the toxin content of the standard 100-unit option. As a result, it suits larger treatment areas or combined facial and body sessions.

In the United States, Hugel markets the same underlying formulation under the brand name Letybo. Letybo received FDA approval in 2024, reflecting the depth of clinical study behind the Botulax formulation. Hugel purifies each batch to over 99% using Size Exclusion High Performance Liquid Chromatography (SE-HPLC).

At a Glance

Units per Vial	200 units
Onset	Visible within 4–6 weeks; early changes often sooner
Duration	3–4 months per session
Purity	>99% (SE-HPLC purification)
Manufacturer	Hugel, Inc., South Korea

Main Benefits

• Smooths wrinkles and fine lines: relaxes facial muscles to reduce frown lines and crow’s feet
• Covers larger areas per vial: 200 units reduces the need for multiple vials in bigger sessions
• High purity and quality: over 99% purity supports a clean formulation and consistent results
• Fast-acting and long-lasting: results typically appear within weeks and last several months

What’s Inside

Active Ingredient	Clostridium botulinum toxin type A — 200 units
Stabilizer	Human serum albumin — 1.0mg
Additive	Sodium chloride
Strain	Clostridium Botulinum CBFC26
Format	Lyophilized powder, single-dose vial
Manufacturer	Hugel, Inc., South Korea

Packaging and included accessories (syringes, saline, gloves) vary by supplier — check your specific listing for exact kit contents.

How Botulax Is Made

Hugel purifies the active ingredient using Size Exclusion High Performance Liquid Chromatography, which removes impurities and supports consistent potency. The finished product arrives as a fine powder in a sterile vial, ready for reconstitution with 0.9% saline. Across multiple clinical trials, Botulax has shown stability, efficacy, and safety comparable to other established brands. It remains stable when stored at 2–8°C.

What Botulax Is Made Of

Clostridium Botulinum Toxin Type A	A purified neurotoxic protein that temporarily blocks nerve signals to targeted muscles, reducing dynamic facial wrinkles
Human Serum Albumin	A protein that stabilizes the toxin and helps maintain effectiveness after reconstitution
Sodium Chloride	Helps balance the solution’s pH and tonicity for safe injection

Mechanism of Action

Once injected, botulinum toxin type A blocks the release of acetylcholine, the neurotransmitter responsible for triggering muscle contraction. Because the treated muscle can no longer contract as forcefully, the movement that causes wrinkles decreases. As a result, expression lines soften, creating a more refreshed appearance. When a trained professional administers it correctly, the effect stays localized to the injected muscle and does not spread through the body.

Preparation & Dilution

Botulax comes as a fine powder that must be reconstituted with saline before use. Because the powder is so fine, the vial can look nearly empty. This is normal, and the full dose remains present.

Materials needed: 0.9% sterile saline, a sterile syringe (typically 30G), latex gloves, and alcohol swabs.

Saline Added (200U vial)	Resulting Concentration
2.0mL	10 units per 0.1mL
4.0mL	5 units per 0.1mL
5.0mL	4 units per 0.1mL
8.0mL	2.5 units per 0.1mL

1. Inspect the vial: it should be colorless and transparent with a small quantity of white or light yellow powder visible
2. Draw the saline into a syringe and slowly inject it into the vial
3. Gently swirl to mix — do not shake vigorously
4. Confirm the solution is clear and free of particles before drawing a dose
5. Store refrigerated at 2–8°C and use within 24 hours

Treatment Areas

Face:

• Glabellar lines (between the eyebrows)
• Forehead lines
• Crow’s feet
• Lower face and jawline (muscle contouring)
• Around the eyes (blepharospasm treatment)

Body:

• Areas affected by muscle spasticity
• Upper limbs (post-stroke spasticity)
• Lower limbs, including equinus foot deformity in children with cerebral palsy
• Combined facial and body sessions in one visit, given the higher unit count

Dosage & Technique

Dosage and injection technique vary by treatment area and patient condition. A licensed professional trained in botulinum toxin injection should determine the exact plan. General reference guidelines include:

• Benign essential blepharospasm: injected into the muscles surrounding the eyes in adult patients
• Post-stroke upper limb spasticity: injected into affected muscle groups in patients aged 20 and older
• Equinus foot deformity in cerebral palsy: administered to lower limb muscles in children aged 2 and older
• Glabellar lines: used to treat moderate to severe frown lines from repeated facial expression

Post-Treatment Care

• Avoid rubbing or massaging the treated area for at least 24 hours
• Stay upright and avoid lying down for 4 to 6 hours after treatment
• Avoid strenuous exercise for 24 to 48 hours
• Skip saunas, hot tubs, and excessive sun exposure for at least 24 hours
• Delay facials, microdermabrasion, or chemical peels for at least 1 week
• Mild redness, swelling, or bruising can occur and usually resolves within a few days

Course of Treatment

1 session	Typically enough to achieve visible wrinkle reduction
3–4 months	How long results from a single session generally last
3–6 months	Recommended interval for repeat treatment to maintain results

Most patients notice initial changes within a few weeks. Clinical follow-ups often confirm visible improvement at the 4, 6, and 12-week marks.

Precautions

• For use by licensed medical professionals only
• Contraindicated in patients with neuromuscular junction disorders, such as myasthenia gravis
• Contraindicated during pregnancy or breastfeeding
• Avoid in patients with active infection at the injection site
• Proper training in injection technique and facial anatomy is essential for safe use

Storage & Handling

• Store unopened vials refrigerated at 2–8°C
• Do not freeze
• Use within 24 hours after reconstitution; some data suggests stability up to 5 weeks under refrigeration, though 24 hours remains the standard recommendation

Botulinum toxin type A is a prescription medical product for use by licensed healthcare professionals only. Botulax itself is distinct from the FDA-approved Letybo product marketed in the United States. Availability may be restricted for US customers, so check current regulations before ordering.

Frequently Asked Questions

What is Botulax 200UI?
Botulax 200UI is a high-purity botulinum toxin type A product from Hugel, offering double the standard unit count for larger treatment sessions.

Who is the 200UI vial best suited for?
Practitioners treating combined facial and body areas, larger muscle groups, or multiple zones in one session often prefer it, since it reduces the need for multiple vials.

Are results immediate?
No. Most patients notice changes within a few weeks, with clinical studies showing improvement confirmed at 4, 6, and 12-week follow-ups.

Is Botulax the same as Letybo?
Letybo is the brand name Hugel uses to market this same formulation in the United States, where it received FDA approval in 2024.

How is Botulax 200UI different from the 100UI version?
Both share the same formulation and manufacturer. The 200UI vial simply contains double the toxin units and slightly more stabilizer, reducing the need for multiple vials in larger sessions.

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